Skeletal-muscle glycogen synthesis during the starved-to-fed transition in the rat
| Autor: | M C Sugden, M J Holness, M J L Schuster-Bruce |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_specialty
Biochemistry Glycogen debranching enzyme chemistry.chemical_compound Internal medicine medicine Glycogen branching enzyme Animals Glycogen synthase Molecular Biology biology Glycogen Muscles Skeletal muscle Rats Inbred Strains Cell Biology Metabolism Carbohydrate Liver Glycogen Rats Endocrinology medicine.anatomical_structure chemistry Food Starvation Glycogenesis biology.protein Female Research Article |
| Zdroj: | Biochemical Journal. 254:855-859 |
| ISSN: | 1470-8728 0264-6021 |
| Popis: | The pattern of glycogen deposition in skeletal muscles of varying fibre composition was examined in rats during the starved-to-fed transition. In all the muscles studied, glycogen concentrations steadily increased during the first 8 h after chow re-feeding, and the fed value was exceeded. Rates of glycogen deposition varied, not with muscle fibre composition, but with the extent of glycogen depletion during starvation. There was no evidence for skeletal-muscle glycogen breakdown during the period of hepatic glycogenesis, making it unlikely that recycling of carbon from muscle glycogen to lactate is quantitatively important for the provision of glycogenic precursors to the liver, but moderate glycogen loss was observed from 8 to 24 h after re-feeding, when the liver is in the lipogenic mode. The factors influencing glucose disposal by skeletal muscle after re-feeding are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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