Perfluoroalkyl Chemicals, Menstrual Cycle Length, and Fecundity
| Autor: | Dana B. Barr, Thomas A. Louis, Kirsten J. Lum, Germaine M. Buck Louis, Rajeshwari Sundaram |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Michigan medicine.medical_specialty Time Factors Pregnancy Rate Epidemiology media_common.quotation_subject Physiology Fertility 010501 environmental sciences 01 natural sciences Article 03 medical and health sciences 0302 clinical medicine Pregnancy Tandem Mass Spectrometry medicine Humans Prospective Studies Prospective cohort study Menstrual Cycle Menstrual cycle Menstrual cycle length 0105 earth and related environmental sciences media_common Gynecology Fluorocarbons Sulfonamides 030219 obstetrics & reproductive medicine business.industry Chromatography liquid Bayes Theorem Fecundity medicine.disease Texas Pregnancy rate Alkanesulfonic Acids Environmental Pollutants Female Caprylates business Decanoic Acids Chromatography Liquid |
| Zdroj: | Epidemiology. 28:90-98 |
| ISSN: | 1044-3983 |
| DOI: | 10.1097/ede.0000000000000552 |
| Popis: | Perfluoroalkyl substances have been associated with changes in menstrual cycle characteristics and fecundity, when modeled separately. However, these outcomes are biologically related, and we evaluate their joint association with exposure to perfluoroalkyl substances.We recruited 501 couples from Michigan and Texas in 2005-2009 upon their discontinuing contraception and followed them until pregnancy or 12 months of trying. Female partners provided a serum sample on enrollment and completed daily journals on menstruation, intercourse, and pregnancy test results. We measured seven perfluoroalkyl substances in serum using liquid chromatography-tandem mass spectrometry. We assessed the association between perfluoroalkyl substances and menstrual cycle length using accelerated failure time models and between perfluoroalkyl substances and fecundity using a Bayesian joint modeling approach to incorporate cycle length.Menstrual cycles were 3% longer comparing women in the second versus first tertile of perfluorodecanoate (PFDeA; acceleration factor [AF] = 1.03, 95% credible interval [CrI] = [1.00, 1.05]), but 2% shorter for women in the highest versus lowest tertile of perfluorooctanoic acid (PFOA; AF = 0.98, 95% CrI = [0.96, 1.00]). When accounting for cycle length, relevant covariates, and remaining perfluoroalkyl substances, the probability of pregnancy was lower for women in second versus first tertile of perfluorononanoate (PFNA; odds ratio [OR] = 0.6, 95% CrI = [0.4, 1.0]) although not when comparing the highest versus lowest (OR = 0.7, 95% CrI = [0.3, 1.1]) tertile.In this prospective cohort study, we observed associations between two perfluoroalkyl substances and menstrual cycle length changes, and between select perfluoroalkyl substances and diminished fecundity at some (but not all) concentrations. See video abstract at, http://links.lww.com/EDE/B136. |
| Databáze: | OpenAIRE |
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