The leuprolide flare regime for in-vitro fertilization/gamete intra-Fallopian transfer and embryo cryopreservation
| Autor: | C.A. Kirby, G. M. Warnes, C.D. Matthews, X. Wang, G. Phillipson, Robert J. Norman |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
media_common.quotation_subject medicine.medical_treatment Radioimmunoassay Fertilization in Vitro Biology Drug Administration Schedule Cryopreservation Andrology Human fertilization Embryo cryopreservation medicine Humans Gamete intrafallopian transfer Ovulation media_common Gynecology Pregnancy In vitro fertilisation Rehabilitation Obstetrics and Gynecology Embryo Mammalian medicine.disease Gamete Intrafallopian Transfer Reproductive Medicine Female Leuprolide Menotropins |
| Zdroj: | Human Reproduction. 6:817-822 |
| ISSN: | 1460-2350 0268-1161 |
| DOI: | 10.1093/oxfordjournals.humrep.a137434 |
| Popis: | Gonadotrophin releasing hormone agonists (GnRHa) are now well established as adjuvant agents for in-vitro fertilization (IVF)/gamete intra-Fallopian transfer (GIFT) but several different modes of usage have been proposed. Our experience with 328 cycles of leuprolide used in a flare regime is reviewed. An endocrinologically proven flare effect was associated with a reduction of human menopausal gonadotrophin (HMG) usage (10 versus 16 ampoules) and a lower cycle cancellation/conversion rate (7.4 versus 11.3%). Overall, satisfactory rates of oocyte recovery (93%, mean number of oocytes 7.0), clinical pregnancy (24.4% per oocyte recovery) and pregnancy from frozen/thawed embryo transfers (14%) were achieved. The flare protocol appears to be a satisfactory choice for the majority of subjects but careful monitoring is required to avoid the potential for ovarian hyperstimulation. |
| Databáze: | OpenAIRE |
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