Genetic effects of 1,2-dibromo-3-chloropropane (DBCP) in drosophila
| Autor: | P. G. Kale, John W. Baum |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
endocrine system Time Factors biology 1 2-Dibromo-3-chloropropane Health Toxicology and Mutagenesis Genes Recessive Chromosomal translocation Embryo biology.organism_classification Embryonic stem cell Molecular biology Chromosomal crossover Propane chemistry.chemical_compound Drosophila melanogaster chemistry Botany Genetics Animals Genes Lethal Drosophila (subgenus) Mutagens |
| Zdroj: | Environmental Mutagenesis. 4:681-687 |
| ISSN: | 1930-238X 0192-2521 |
| DOI: | 10.1002/em.2860040607 |
| Popis: | Induction of sex-linked recessive lethal mutations, heritable translocations and genetic crossing-over were studied in Drosophila melanogaster males treated as adults and as embryos with different concentrations of gaseous DBCP. Adults exposed to 30 ppm/hr of the compound did not produce a significant number of sex-linked recessive lethal mutations in treated spermatozoa, spermatids, or spermatocytes. However, at an exposure of 17.7 ppm/hr, a weak mutagenic effect was observed in embryonic spermatogonia. No translocation was scored in 4032 tested chromosomes from adults treated with 150 ppm/hr. However, a significant number of spermatocytial crossovers were induced after an exposure of 120 ppm/hr. |
| Databáze: | OpenAIRE |
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