Pediatric Bacterial Meningitis Surveillance in Niger: Increased Importance of Neisseria meningitidis Serogroup C, and a Decrease in Streptococcus pneumoniae Following 13-Valent Pneumococcal Conjugate Vaccine Introduction
| Autor: | Peter Sylvanus Ndow, Mamadou Kourna Hama, Brenda Kwambana-Adams, Dam Khan, Joseph Nsiari-Muzeyi Biey, Boubou Laouali, Moussa Haladou, Archibald Worwui, Catherine Okoi, Ricardo Nse Obama, Bernard Ntsama, Jason M. Mwenda, Martin Antonio, Abdoulaye Yam |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) Serotype 030106 microbiology Supplement Articles Neisseria meningitidis Serogroup C Serogroup medicine.disease_cause cerebrospinal fluid Pneumococcal conjugate vaccine Meningitis Bacterial Microbiology Haemophilus influenzae Pneumococcal Vaccines 03 medical and health sciences Streptococcus pneumoniae medicine Humans Niger Serotyping Antiinfective agent Whole Genome Sequencing Immunization Programs business.industry Neisseria meningitidis Infant Newborn meningitis Infant medicine.disease Hospitals S. pneumoniae Vaccination 030104 developmental biology Infectious Diseases N. meningitidis Child Preschool Population Surveillance Female business Meningitis medicine.drug |
| Zdroj: | Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America |
| ISSN: | 1537-6591 1058-4838 |
| Popis: | Background Meningitis is endemic in Niger. Haemophilus influenzae type b (Hib) vaccine and the 13-valent pneumococcal conjugate vaccine (PCV13) were introduced in 2008 and 2014, respectively. Vaccination campaign against Neisseria meningitidis serogroup A was carried out in 2010–2011. We evaluated changes in pathogen distribution using data from hospital-based surveillance in Niger from 2010 through 2016. Methods Cerebrospinal fluid (CSF) specimens from children Numbers of Streptococcus pneumoniae meningitis decreased following 13-valent pneumococcal conjugate vaccine introduction in 2014. The case fatality rate of S. pneumoniae meningitis was higher compared with both Haemophilus influenzae and Neisseria meningitidis meningitis. Increased importance of N. meningitidis serogroup C was observed. |
| Databáze: | OpenAIRE |
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