Derivation of an HIV Risk Score for African Women Who Engage in Sex Work
| Autor: | Alexandra C Willcox, Emmanuel Kabare, Julie Overbaugh, John Kinuthia, Juma Shafi, Walter Jaoko, Kishorchandra Mandaliya, R Scott McClelland, Barbra A. Richardson |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Social Psychology Population HIV Infections Article 03 medical and health sciences 0302 clinical medicine Risk Factors Humans Medicine Medroxyprogesterone acetate 030212 general & internal medicine education Survival analysis Sex work education.field_of_study Sex Workers 030505 public health Framingham Risk Score business.industry Incidence Public health Public Health Environmental and Occupational Health virus diseases Kenya Sex Work Health psychology Infectious Diseases Cohort Female Pre-Exposure Prophylaxis 0305 other medical science business Demography medicine.drug |
| Zdroj: | AIDS Behav |
| ISSN: | 1573-3254 1090-7165 |
| Popis: | No tool exists to stratify HIV risk in contemporary African female sex worker (FSW) populations. Data from a cohort of HIV-negative FSWs in Mombasa, Kenya from 2010 to 2017 were used to conduct a survival analysis assessing predictors of HIV infection. Stepwise regression was used to construct a multivariable model that formed the basis for the score. Seventeen HIV infections occurred over 1247 person-years of follow-up contributed by 670 women. Using depot medroxyprogesterone acetate (DMPA), having a curable sexually transmitted infection (STI), and being married contributed points to the score. HIV incidence was 0.85/100 person-years in a lower-risk group and 3.10/100 person-years in a higher-risk group. In a cohort with overall HIV incidence < 1.50/100 person-years, this risk score identified a subgroup of FSWs with HIV incidence > 3.00/100 person-years, which is the threshold used by the World Health Organization for initiating pre-exposure prophylaxis (PrEP). If validated in an external population, this tool could be useful for targeted PrEP promotion among higher-risk FSWs. |
| Databáze: | OpenAIRE |
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