A Randomized Controlled Trial of the Effects of Mindfulness-Based Stress Reduction (MBSR[BC]) on Levels of Inflammatory Biomarkers Among Recovering Breast Cancer Survivors
| Autor: | Thomas W. Klein, Jong Y. Park, Kevin E. Kip, Maya Elias, Carly L. Paterson, Manolete S. Moscoso, Alice Le, Cathy Newton, Cecile A. Lengacher, Carissa B. Alinat, Richard R. Reich, Matthew Goodman, Steve Shivers, Sophia Ramesar, Versie Johnson-Mallard |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Oncology
Adult medicine.medical_specialty medicine.medical_treatment Breast Neoplasms law.invention Mindfulness-based stress reduction 03 medical and health sciences 0302 clinical medicine Breast cancer Randomized controlled trial Cancer Survivors law Internal medicine medicine Humans Inflammation Research and Theory business.industry Interleukin Venous blood Articles Middle Aged medicine.disease Cytokine 030220 oncology & carcinogenesis Immunology Cytokines Tumor necrosis factor alpha Female business Mindfulness 030217 neurology & neurosurgery Biomarkers Stress Psychological Transforming growth factor |
| Popis: | Purpose: The purpose of this substudy of a large randomized controlled trial was to evaluate the efficacy of the Mindfulness-Based Stress Reduction (Breast Cancer) (MBSR[BC]) program compared to usual care (UC) in normalizing blood levels of pro-inflammatory cytokines among breast cancer survivors (BCS). Method: A total of 322 BCS were randomized to either a 6-week MBSR(BC) program or a UC. At baseline and 6 and 12 weeks, 10 ml of venous blood and demographic and clinical data were collected and/or updated. Plasma cytokines (interleukin [IL]-1β, IL-6, IL-10, tumor necrosis factor [TNF] α, transforming growth factor [TGF] β1, soluble tumor necrosis factor receptor [sTNFR] 1) were assayed. Linear mixed models were used to assess cytokine levels across three time points (baseline and 6 and 12 weeks) by group (MBSR[BC] vs. UC). Results: Of the six measured cytokines, three were nondetectable at rates greater than 50% (IL-10, IL-1β, TGF-β1) and, because of overall low prevalence, were not analyzed further. For the remaining cytokines (TNFα, IL-6, sTNFR1), results showed that TNFα and IL-6 increased during the follow-up period (between 6 and 12 weeks) rather than during the MBSR(BC) training period (between baseline and 6 weeks), while sTNFR1 levels did not change significantly across the 12-week period. Conclusions: Study results suggest that MBSR(BC) affects cytokine levels in BCS, mainly with increases in TNFα and IL-6. The data further suggest that B-cell modulation may be a part of immune recovery during breast cancer management and that increases in TNFα and IL-6 may be markers for MBSR(BC)-related recovery. |
| Databáze: | OpenAIRE |
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