Anti-Urolithiatic Effect of Cow Urine Ark on Ethylene Glycol-Induced Renal Calculi
| Autor: | Seema N. Baxi, Divyesh R. Mandavia, Apexa Bhanuprasad Shukla, Manish J Barvaliya, Chandrabhanu Tripathi |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Ethylene Glycol medicine.medical_specialty Time Factors Urology Calcium oxalate chemistry.chemical_element Urine Calcium lcsh:RC870-923 Oxalate Kidney Calculi Random Allocation chemistry.chemical_compound Internal medicine medicine Animals Urea Creatinine Calcium Oxalate business.industry Reproducibility of Results Organ Size lcsh:Diseases of the genitourinary system. Urology Rats Treatment Outcome Endocrinology chemistry Distilled water Cattle business Ethylene glycol |
| Zdroj: | International Brazilian Journal of Urology, Vol 39, Iss 4, Pp 565-571 (2013) International braz j urol, Volume: 39, Issue: 4, Pages: 565-571, Published: JUL 2013 International braz j urol v.39 n.4 2013 International Braz J Urol Sociedade Brasileira de Urologia (SBU) instacron:SBU |
| ISSN: | 1677-5538 |
| DOI: | 10.1590/s1677-5538.ibju.2013.04.15 |
| Popis: | Purpose To investigate the anti-urolithiatic effect of cow urine ark (medicinal distilled cow urine) on ethylene glycol (EG) induced renal calculi. Materials and Methods 36 male Wistar rats were randomly divided into 6 equal groups. Group I animals served as vehicle control and received distilled water for 28 days. Group II to VI animals received 1% v/v EG in distilled water for 28 days. Group II served as EG control. Group III and IV (preventive groups) received cow urine ark orally for 28 days in doses of 1 mL/kg and 2 mL/kg, respectively. Group V and VI (treatment groups) received 1 mL/kg and 2 mL/kg cow urine ark orally, respectively from 15th to 28th days. 24-hour urine samples were collected on day 0 and 28. Urine volume and oxalate levels were measured. On day 28, blood was collected for biochemical parameters. Animals were sacrificed and kidneys were harvested, weighed and histopathologically evaluated for calcium oxalate (CaOx) crystals. To calculate the percentage of inhibition of mineralization, simultaneous flow static in-vitro model was used. Results EG significantly increased urine oxalate, serum creatinine, blood urea level; kidney weight and CaOx deposits. Provision of cow urine ark resulted in significantly lower levels of urine oxalate, serum creatinine, blood urea and CaOx depositions as compared to Group II. (p value < 0.05) It also significantly restored kidney weight. (p value < 0.05) Cow urine ark inhibited 40% and 35% crystallization of CaOx and calcium phosphate, respectively. Conclusion Cow urine ark is effective in prevention and treatment of EG induced urolithiasis in Wistar rats. |
| Databáze: | OpenAIRE |
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