Angiogenin (ANG)—Ribonuclease Inhibitor (RNH1) System in Protein Synthesis and Disease
| Autor: | Mayuresh Anant Sarangdhar, Ramanjaneyulu Allam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Transcription
Genetic Angiogenin Ribosome biogenesis 610 Medicine & health Review Ribosome Catalysis Inorganic Chemistry lcsh:Chemistry RNA Transfer Translational regulation Angiogenin (ANG) Protein biosynthesis Animals Humans RNases transcript-specific translation and ribosomopathies Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy Cell Nucleus ribosomal heterogeneity Chemistry Organic Chemistry Translation (biology) Ribonuclease Pancreatic General Medicine RRNA transcription Computer Science Applications Cell biology Protein Transport Ribonuclease inhibitor (RNH1) lcsh:Biology (General) lcsh:QD1-999 RNA Ribosomal Protein Biosynthesis Transfer RNA Carrier Proteins mRNA translation regulation |
| Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 1287, p 1287 (2021) Sarangdhar, Mayuresh Anant; Allam, Ramanjaneyulu (2021). Angiogenin (ANG)—Ribonuclease Inhibitor (RNH1) System in Protein Synthesis and Disease. International journal of molecular sciences, 22(3), p. 1287. MDPI 10.3390/ijms22031287 International Journal of Molecular Sciences |
| ISSN: | 1661-6596 1422-0067 |
| DOI: | 10.3390/ijms22031287 |
| Popis: | Protein synthesis is a highly complex process executed by well-organized translation machinery. Ribosomes, tRNAs and mRNAs are the principal components of this machinery whereas RNA binding proteins and ribosome interacting partners act as accessory factors. Angiogenin (ANG)—Ribonuclease inhibitor (RNH1) system is one such accessory part of the translation machinery that came into focus afresh due to its unconventional role in the translation. ANG is conventionally known for its ability to induce blood vessel formation and RNH1 as a “sentry” to protect RNAs from extracellular RNases. However, recent studies suggest them to be important in translation regulation. During cell homeostasis, ANG in the nucleus promotes rRNA transcription. While under stress, ANG translocates to the cytosol and cleaves tRNA into fragments which inhibit ribosome biogenesis and protein synthesis. RNH1, which intimately interacts with ANG to inhibit its ribonucleolytic activity, can also bind to the 40S ribosomes and control translation by yet to be known mechanisms. Here, we review recent advancement in the knowledge of translation regulation by the ANG-RNH1 system. We also gather information about this system in cell homeostasis as well as in pathological conditions such as cancer and ribosomopathies. Additionally, we discuss the future research directions and therapeutic potential of this system. |
| Databáze: | OpenAIRE |
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