ACTH-elicited sodium appetite in sheep
| Autor: | John P. Coghlan, JS Fan, Michael J. McKinley, J. F. Nelson, S. Hatzikostas, B. A. Scoggins, Derek A. Denton, R. S. Weisinger |
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| Rok vydání: | 1980 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Physiology Endocrinology Diabetes and Metabolism Sodium media_common.quotation_subject Drinking Appetite chemistry.chemical_element Sodium Chloride Calcium Potassium Chloride Excretion Calcium Chloride chemistry.chemical_compound Adrenocorticotropic Hormone Corticosterone Physiology (medical) Internal medicine Extracellular fluid medicine Animals Infusions Parenteral media_common Sheep Aldosterone Water Endocrinology chemistry Female hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | American Journal of Physiology-Endocrinology and Metabolism. 239:E45-E50 |
| ISSN: | 1522-1555 0193-1849 |
| Popis: | Intramuscular injections of long-acting synthetic ACTH (45 U twice daily for 5 days) caused a large increase in the intake of 0.5 M NaCl in sheep. Mean Na intake of the sheep on the last 3 days of treatment approximated 50% of their total extracellular fluid Na. The mineral appetite was specific for NaCl. Intakes of 0.5 M KCl or 0.25 M CaCl2 were not significantly altered. The enhanced appetite for Na induced by ACTH appeared to precede any increase in urinary Na excretion. ACTH treatment was ineffective in adrenalectomized sheep. However, an infusion into adrenalectomized sheep of a combination of adrenal steroid hormones (including aldosterone, deoxycorticosterone, 11-deoxycortisol, cortisol, and corticosterone) that contrived blood levels similar to those, obtained with ACTH treatment in normal sheep did induce Na appetite. Thus, ACTH induces a specific, adrenal-steroid hormone-dependent Na appetite in sheep. |
| Databáze: | OpenAIRE |
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