Ablative radiotherapy for liver tumors using stereotactic MRI-guidance: A prospective phase I trial
| Autor: | Michael L. Steinberg, Daniel A. Low, Ritchell van Dams, Ann C. Raldow, Minsong Cao, Fang-I Chu, James Lamb, Amar U. Kishan, Argin G. Mikaeilian, Percy Lee, Trudy C. Wu, J. Hernandez |
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| Rok vydání: | 2021 |
| Předmět: |
High rate
business.industry Stereotactic body radiation therapy medicine.medical_treatment Liver Neoplasms Hematology Radiosurgery Magnetic Resonance Imaging Radiation therapy Oncology Median follow-up Ablative case Toxicity medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Nuclear medicine business Methods treatment Radiotherapy Image-Guided |
| Zdroj: | Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. 170 |
| ISSN: | 1879-0887 |
| Popis: | Background and purpose To prospectively determine the feasibility, safety, and efficacy of stereotactic body radiation therapy (SBRT) to primary and secondary liver tumors with MR-guided radiation therapy (MRgRT). Materials and methods Treatment plans with a conventional CT-guided linear accelerator and a MRI-guided tri-60Co teletherapy unit (MR-Co) were generated and compared for patients undergoing liver-directed SBRT from 2015 to 2017. If dosimetric parameters were met on MR-Co, patients were treated with MRgRT. The highest priority constraint was >1000 cc or >800 cc of normal liver receiving Results Of 23 patients screened, 20 patients (8 primary, 12 secondary) and 25 liver tumors underwent MR-guided SBRT to a median dose of 54 Gy (range 11.5-60) in a median of 3 fractions (range 1-5). With a median follow up of 18.9 months, the 1- and 2-year estimate of local control were 94.7% and 79.6%, respectively. A difference in local control between single and multiple lesions or BED ≥100Gy10 and BED Conclusion MR-guided SBRT is a viable and safe option in the delivery of ultrahypofractionated ablative radiation treatment to primary and secondary liver tumors resulting in high rates of local control and very favorable toxicity profiles. |
| Databáze: | OpenAIRE |
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