[166Dy]Dysporium/[166Ho]Holmium In Vivo generator
| Autor: | Nadine Di Bartolo, Saed Mirzadeh, Furn F. Knapp, Suzanne V. Smith, R. M. Lambrecht, E L Hetherington |
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| Rok vydání: | 1995 |
| Předmět: |
Biodistribution
Kinetics chemistry.chemical_element Chromosomal translocation Bone and Bones Holmium Mice Nuclear magnetic resonance Bone Marrow In vivo Dysprosium Organometallic Compounds medicine Animals Humans Tissue Distribution Beta (finance) Serum Albumin Radioisotopes Mice Inbred BALB C Radiation Chemistry Pentetic Acid In vitro medicine.anatomical_structure Biophysics Nucleus |
| Zdroj: | Applied Radiation and Isotopes. 46:759-764 |
| ISSN: | 0969-8043 |
| DOI: | 10.1016/0969-8043(94)00149-t |
| Popis: | A novel approach for the delivery of 166Ho (t1/2 = 26.6 h) to tissue is via the in vivo decay of its 81.5 h parent, 166Dy-an in vivo generator system. A critical question for the in vivo 166Dy/166Ho generator system is whether translocation of the daughter nucleus occurs. The in vitro and in vivo integrity of the [166Dy]Dy/166Ho-DTPA complex was investigated and results indicated that no translocation of the daughter nucleus occurs subsequent to beta- decay of 166Dy. Biodistribution studies of [166Dy]Dy-DTPA showed that the ratio of 166Dy/166Ho in bone remains constant (+/- 7%) over a 20 h period, indicating no significant in vivo loss of 166Ho from the complex. Increasing the in vivo residence time of [166Dy]Dy-DTPA complex attached to HSA gave similar results. |
| Databáze: | OpenAIRE |
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