Effects of Maternal Ethanol Consumption and Buspirone Treatment on Dopamine and Norepinephrine Reuptake Sites and D1 Receptors in Offspring
| Autor: | Jason L Eriksen, Hong‐Lin Hao, Roberta A. Gillespie, Mary J. Druse |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Agonist medicine.medical_specialty medicine.drug_class Offspring Dopamine Medicine (miscellaneous) Toxicology Buspirone Reuptake Rats Sprague-Dawley Norepinephrine Dorsal raphe nucleus Internal medicine medicine Animals Dose-Response Relationship Drug business.industry Receptors Dopamine D1 Brain Rats Receptors Adrenergic Psychiatry and Mental health Endocrinology Anti-Anxiety Agents Fetal Alcohol Spectrum Disorders 5-HT1A receptor Female Serotonin business medicine.drug |
| Zdroj: | Alcoholism: Clinical and Experimental Research. 21:452-459 |
| ISSN: | 0145-6008 |
| DOI: | 10.1111/j.1530-0277.1997.tb03790.x |
| Popis: | Previously, it was shown that in utero ethanol exposure results in decreased serotonin (5-HT) and altered concentrations of 5-HT reuptake sites and 5-HT 1A receptors in fetal and/or postnatal rats. Because fetal 5-HT is an essential trophic factor, this laboratory previously investigated the hypotheses that the early ethanol-associated 5-HT deficit contributed to subsequent development abnormalities in the serotonergic system and that the effects of the fetal 5-HT deficit could be prevented by maternal treatment with buspirone, a 5-HT 1A receptor agonist. The present report determined the effects of maternal treatment with buspirone on two other neurotransmitter systems in the developing offspring of ethanol-fed dams: dopamine (DA) and norepinephrine reuptake sites and D1 receptors in postnatal day 19 offspring of control and ethanol-fed dams, that received daily injections of saline or 4.5 mg/kg buspirone. These investigations found that in utero ethanol exposure significantly decreased norepinephrine reuptake sites in the dorsomedial hypothalamic nucleus and anteroventral thalamic nucleus. There was also an ethanol effect in the dorsal raphe. D1 receptors were moderately increased (5-10% increase) in the striatum, and DA reuptake sites were unchanged in PN19 ethanol-exposed offspring. No other significant ethanol-related effects were noted. Maternal buspirone treatment did not adversely affect the concentration of DA reuptake sites or D1 receptors in control rats. Thus, whereas buspirone exerts protective effects on the developing 5-HT system of ethanol-exposed rats, it does not appear to damage the development of the DA system. Matemal buspirone produced only one significant abnormality in control offspring; it resulted in a significant reduction of norepinephrine reuptake sites in the DR. |
| Databáze: | OpenAIRE |
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