Phase I trial of MS-275, a histone deacetylase inhibitor, administered weekly in refractory solid tumors and lymphoid malignancies
| Autor: | Erin R. Gardner, Kyunghwa Hwang, Alice P. Chen, Martin Gutierrez, Kim Maynard, James H. Doroshow, Barbara A. Conley, Jane B. Trepel, Min-Jung Lee, Qin C. Ryan, Anthony J. Murgo, James A. Zwiebel, Giovanni Melillo, William D. Figg, Erin E. Donovan, Mikhail Kalnitskiy, Shivaani Kummar, Eun Joo Chung |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Cancer Research Maximum Tolerated Dose medicine.drug_class Pyridines Antineoplastic Agents Pharmacology Peripheral blood mononuclear cell Drug Administration Schedule Pharmacokinetics Neoplasms medicine Humans Hypoalbuminemia Enzyme Inhibitors Aged business.industry Lymphoma Non-Hodgkin Histone deacetylase inhibitor Middle Aged medicine.disease Histone Deacetylase Inhibitors Oncology Pharmacodynamics Toxicity Immunology Benzamides Female Hyponatremia business Hypophosphatemia |
| Zdroj: | Clinical cancer research : an official journal of the American Association for Cancer Research. 13(18 Pt 1) |
| ISSN: | 1078-0432 |
| Popis: | Purpose: MS-275 is a histone deacetylase inhibitor that has shown potent and unique anticancer activity in preclinical models. The aims of this phase I trial were to determine the dose-limiting toxicities and maximum tolerated dose of oral MS-275 in humans administered with food on a once weekly schedule and to study the pharmacokinetics of oral MS-275. Experimental Design: Patients with refractory solid tumors and lymphoid malignancies were treated with oral MS-275 on a once weekly schedule for 4 weeks of a 6-week cycle. Samples for pharmacokinetic and pharmacodynamic analyses were collected during cycle 1. Protein acetylation in subpopulations of peripheral blood mononuclear cells was measured using a multivariable flow cytometry assay. Results: A total of 22 patients were enrolled, and 19 were considered evaluable for toxicity. The maximum tolerated dose was 6 mg/m2. No National Cancer Institute Common Toxicity Criteria grade 4 toxicities were observed. Dose-limiting grade 3 toxicities were reversible and consisted of hypophosphatemia, hyponatremia, and hypoalbuminemia. Non–dose-limiting grade 3 myelosuppression was also observed. The mean terminal half-life of MS-275 was 33.9 ± 26.2 and the Tmax ranged from 0.5 to 24 h. Although there was considerable interpatient variability in pharmacokinetics, the area under the plasma concentration versus time curve increased linearly with dose. Conclusions: MS-275 is well tolerated at a dose of 6 mg/m2 administered weekly with food for 4 weeks every 6 weeks. Drug exposure increases linearly with dose, and protein acetylation increased in all the subpopulations of peripheral blood mononuclear cells following MS-275 administration. |
| Databáze: | OpenAIRE |
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