Central nervous system solitary fibrous tumour/hemangiopericytoma presenting as nausea, vomiting and hepatic dysfunction after the first trimester of pregnancy: A case report
| Autor: | Ying Ju, Jun Yang, Huiling Wang, Xu Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
BC
conjugated bilirubin medicine.medical_treatment VEGF Vascular endothelial growth factor AST aspartate aminotransferase Brain herniation 0302 clinical medicine Pregnancy Nausea and vomiting HCG human chorionic gonadotrophin HG hyperemesis gravidarum General anaesthesia 030212 general & internal medicine 030219 obstetrics & reproductive medicine medicine.diagnostic_test CNS Central nervous system CD34 Cell differentiation factor 34 Obstetrics and Gynecology PLGF placental growth factor STAT6 signal transducer and activator of transcription 6 CT computed tomography EMA epithelial membrane antigen Vomiting medicine.symptom PABC pregnancy-associated breast cancer Hemangiopericytoma Hepatic dysfunction medicine.medical_specialty S-100 soluble protein-100 Nausea lcsh:Surgery lcsh:Gynecology and obstetrics Article WHO World Health Organization PET positron emission tomography 03 medical and health sciences PLGF ALT alanine aminotransferase medicine Caesarean section TBIL total bilirubin lcsh:RG1-991 business.industry SFT-HPC Solitary fibrous tumour/hemangiopericytoma Magnetic resonance imaging lcsh:RD1-811 medicine.disease Surgery Central nervous system business MRI magnetic resonance imaging |
| Zdroj: | Case Reports in Women's Health, Vol 29, Iss, Pp e00285-(2021) Case Reports in Women's Health |
| ISSN: | 2214-9112 |
| Popis: | Background Solitary fibrous tumour/haemangiopericytoma (SFT-HPC) is a rare fibroblastic mesenchymal neoplasm that develops as a result of the uncontrolled proliferation of mesenchymal fibroblasts and occurs rarely during pregnancy. Case Presentation A 26-year-old woman (G2P1) with an intrauterine pregnancy at 34+4weeks presented at a university hospital with a history of nausea and vomiting since 20 weeks. Other symptoms included slight headache and 5-kg weight loss. She had attended and been admitted to several hospitals during that time. Laboratory evaluation revealed evidence of hepatic dysfunction with elevated liver enzymes. The patient's headache worsened, and magnetic resonance imaging (MRI) showed an extra-axial mass in the right tentorial and supratentorial spaces, with brain herniation. Caesarean section and brain tumour resection were performed under general anaesthesia at the same time. Histopathological analysis revealed HPC (World Health Organization [WHO] grade III). Nausea and vomiting symptoms gradually improved. Postoperatively, the patient underwent fractional external radiotherapy (total amount 50 Gy). There was no evidence of local recurrence of metastases in the follow-up 6 months after surgery. Conclusions Nausea and vomiting are commonly experienced during pregnancy. This often makes patients ignore other aetiologies that cause nausea and vomiting. Central nervous system tumours can mimic the common pregnancy complaint of nausea and vomiting. Although rare in pregnancy, they can adversely affect maternal and fetal survival if untreated. Clinicians should exclude other pathology when the onset of nausea and vomiting is after the first trimester. Highlights • Haemangiopericytoma is a rare and aggressive type of soft tissue sarcoma that arises from pericytes of the capillaries and involves mostly the musculoskeletal system. • Its presentation [[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]] in the central nervous system is very rare. • Diagnosis was made at 34 weeks of pregnancy after several hospital admissions for nausea and vomiting starting at 20 weeks gestation. • There should be a suspicion of pathology when the onset of nausea and vomiting is after the first trimester. |
| Databáze: | OpenAIRE |
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