Brain tryptophan metabolism in schizophrenia: A post mortem study of metabolites on the serotonin and kynurenine pathways in schizophrenic and control subjects
| Autor: | Harry F. Baker, D Risby, G. J. Riley, T. J. Crow, M H Jospeh |
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| Rok vydání: | 1979 |
| Předmět: |
Male
Aging Serotonin medicine.medical_specialty Metabolite Myocardial Infarction Hippocampus chemistry.chemical_compound Sex Factors Internal medicine medicine Humans Kynurenine Aged Pharmacology Temporal cortex 5-Hydroxyindoleacetic acid Putamen Tryptophan Brain Human brain Hydroxyindoleacetic Acid Middle Aged Endocrinology medicine.anatomical_structure chemistry Postmortem Changes Schizophrenia Female Psychology medicine.drug |
| Zdroj: | Psychopharmacology. 62:279-285 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/bf00431959 |
| Popis: | Serotonin (5HT), its chief metabolite 5-hydroxyindoleacetic acid (5 HIAA), its precursor tryptophan, and kynurenine, another metabolite of tryptophan, have been measured in post mortem human brain samples. Concentrations of these metabolites were not found to be significantly different in putamen, hippocampus or temporal cortex from 23 normal subjects compared with 15 subjects in whom a diagnosis of schizophrenia could be restrospectively confirmed. The results have been analysed with respect to cause of death, medication and post mortem changes. Post mortem increases in tryptophan and kynurenine were observed. Some interrelationships between the variables measured within and between the different areas studied are discussed. It is concluded that there is no evidence for a generalised deficit of 5HT in the brain in schizophrenia, nor for gross changes in turnover along the serotonin or kynurenine pathways of tryptophan metabolism in brain. |
| Databáze: | OpenAIRE |
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