Bleeding Independently associated with Mortality after noncardiac Surgery (BIMS): an international prospective cohort study establishing diagnostic criteria and prognostic importance
| Autor: | Flávia Kessler Borges, Sebastian Ribas, Wojciech Szczeklik, Clive Kearon, Michael McGillion, Tomas VanHelder, Philip J. Devereaux, Bruce M Biccard, Ryszard Mizera, Pavel S Roshanov, Vikas Tandon, Richard P. Whitlock, Mohamed Panju, Justin de Beer, Gordon H. Guyatt, Mark Crowther, Andre Lamy, Jessica Spence, Peter A. Kavsak, Amit X. Garg, Marko Simunovic, Lehana Thabane, Jehonathan H. Pinthus, Tej Sheth, Yannick Le Manach, Deborah M. Siegal, Mitchell Winemaker, Daniel I. Sessler, John W. Eikelboom |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty business.industry Proportional hazards model Middle Aged Postoperative Hemorrhage Prognosis 3. Good health Cohort Studies Clinical trial 03 medical and health sciences 0302 clinical medicine Anesthesiology and Pain Medicine 030202 anesthesiology Postoperative mortality Internal medicine medicine Humans Postoperative outcome Female Prospective Studies Prospective cohort study business Noncardiac surgery Aged |
| Zdroj: | British Journal of Anaesthesia. 126:163-171 |
| ISSN: | 0007-0912 0051-2109 |
| DOI: | 10.1016/j.bja.2020.06.051 |
| Popis: | Background We aimed to establish diagnostic criteria for bleeding independently associated with mortality after noncardiac surgery (BIMS) defined as bleeding during or within 30 days after noncardiac surgery that is independently associated with mortality within 30 days of surgery, and to estimate the proportion of 30-day postoperative mortality potentially attributable to BIMS. Methods This was a prospective cohort study of participants ≥45 yr old having inpatient noncardiac surgery at 12 academic hospitals in eight countries between 2007 and 2011. Cox proportional hazards models evaluated the adjusted relationship between candidate diagnostic criteria for BIMS and all-cause mortality within 30 days of surgery. Results Of 16 079 participants, 2.0% (315) died and 36.1% (5810) met predefined screening criteria for bleeding. Based on independent association with 30-day mortality, BIMS was identified as bleeding leading to a postoperative haemoglobin Conclusions Bleeding independently associated with mortality after noncardiac surgery (BIMS), defined as bleeding that leads to a postoperative haemoglobin Clinical trial registration NCT00512109. |
| Databáze: | OpenAIRE |
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