Oxidant and Carbonyl Stress-Related Apoptosis in End-Stage Kidney Disease: Impact of Membrane Flux
| Autor: | Monica Bonello, Petras Dimitri, Ciro Tetta, Claudio Ronco, Massimo de Cal, Francesco Galli, Rattanarat Ranishta, Valeria Bordoni, Nathan W. Levin, Marta Piroddi, Gabriella Salvatori |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male medicine.medical_specialty Apoptosis Peripheral blood mononuclear cell Monocytes Renal Dialysis Immunity Internal medicine medicine Humans Chemistry Membranes Artificial Blood Proteins U937 Cells Hematology General Medicine Middle Aged Oxidants medicine.disease Membrane Endocrinology Membrane protein Advanced oxidation protein products Biochemistry Nephrology Cell culture Kidney Failure Chronic Female Oxidation-Reduction Kidney disease |
| Zdroj: | Blood Purification. 24:149-156 |
| ISSN: | 1421-9735 0253-5068 |
| DOI: | 10.1159/000089452 |
| Popis: | Apoptosis is a highly regulated process which mostly affects cell-mediated immunity. In this open-label, randomized, prospective clinical study, we determined the impact in 10 hemodialysis patients treated with high-, medium-, and low-flux membranes on spontaneous or plasma-induced apoptosis, on monocytes, as well as on oxidant and carbonyl stress. High- and medium-flux membranes significantly reduced patients’ plasma-dependent proapoptotic activity on U937 monocytic cell lines. Patients who had the highest levels of plasma-induced proapoptotic activity exhibited the highest plasma levels of advanced oxidation protein products (AOPPs) and carbonyls. Plasma carbonyl residues but not AOPPs were significantly lowered. Finally, a significant correlation could be drawn between the extent of plasma-induced proapoptotic activity and both plasma carbonyl and AOPP levels. |
| Databáze: | OpenAIRE |
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