In situ photocrosslinkable formulation of nanocomposites based on multi-walled carbon nanotubes and formononetin for potential application in spinal cord injury treatment
| Autor: | Gabrielle Barrozo Novais, Cristiane Bani Corrêa, Luana Renyelle de Oliveira Menezes, Sheilla da Silva Barroso, Ricardo Luiz Cavalcanti de Albuquerque Júnior, Stefane dos Santos, Renata P Morais, Luiz Pereira da Costa, Alessa Caroline Pedroza de Vasconcelos, Juliana Cordeiro Cardoso, Margarete Zanardo Gomes, Patrícia Severino |
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| Rok vydání: | 2020 |
| Předmět: |
food.ingredient
Materials science Cell Survival Ultraviolet Rays Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Bioengineering Chick Embryo 02 engineering and technology Carbon nanotube Spectrum Analysis Raman Gelatin Nanocomposites law.invention 03 medical and health sciences chemistry.chemical_compound symbols.namesake food law Animals Humans Formononetin General Materials Science Fourier transform infrared spectroscopy Spinal Cord Injuries 030304 developmental biology 0303 health sciences Nanocomposite Nanotubes Carbon Hydrogels 021001 nanoscience & nanotechnology Isoflavones Rats Cross-Linking Reagents Photopolymer Chemical engineering chemistry symbols Molecular Medicine Surface modification 0210 nano-technology Raman spectroscopy |
| Zdroj: | Nanomedicine: Nanotechnology, Biology and Medicine. 29:102272 |
| ISSN: | 1549-9634 |
| Popis: | Carbon nanotubes (CN) have been studied to treat spinal cord injuries because of its electrical properties and nanometric dimensions. This work aims to develop a photopolymerizable hydrogel containing CN functionalized with an anti-inflammatory molecule to be used in situ on spinal cord injuries. The CN functionalization step was done using the drug (formononetin). The nanocomposites were characterized by morphological analysis, FTIR, Raman Spectroscopy, thermal analysis and cytotoxicity assays (MTT and HET-CAM). The nanocomposites were incorporated into gelatin methacryloyl hydrogel and exposed to UV light for photopolymerization. The volume of the formulation and the UV exposition time were also analyzed. The CN characterization showed that formononetin acted as a functionalization agent. The functionalized CN showed safe characteristics and can be incorporated in photocrosslinkable formulation. The UV exposition time for the formulation photopolymerization was compatible with the cell viability and also occurred in the injury site. |
| Databáze: | OpenAIRE |
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