Antiischemic effects of nicardipine and nitroglycerin after coronary artery bypass grafting
| Autor: | George J. Despotis, Ioanna Apostolidou, Charles W. Hogue, Nikolaos J. Skubas, Edward L Hauptmann, Demetrios G. Lappas, Colleen McCawley |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Holter monitor Vasodilator Agents Nicardipine Myocardial Ischemia Hemodynamics Coronary Disease Nitroglycerin Postoperative Complications medicine Humans Prospective Studies Derivation Coronary Artery Bypass Infusions Intravenous Aged Dose-Response Relationship Drug medicine.diagnostic_test business.industry Perioperative Middle Aged Dose–response relationship Treatment Outcome medicine.anatomical_structure Anesthesia Electrocardiography Ambulatory Female Surgery Cardiology and Cardiovascular Medicine business Electrocardiography Artery medicine.drug |
| Zdroj: | The Annals of Thoracic Surgery. 67:417-422 |
| ISSN: | 0003-4975 |
| DOI: | 10.1016/s0003-4975(98)01039-x |
| Popis: | Background . We assessed the efficacy of a continuous infusion of nicardipine and nitroglycerin in reducing the incidence and severity of perioperative myocardial ischemia during elective coronary artery bypass grafting procedures in a prospective, randomized, controlled study. Methods . Patients received either nicardipine infusion (0.7 to 1.4 μg · kg · −1 · min −1 ; n=30) or nitroglycerin (0.5 to 1 μg · kg −1 · min −1 ; n=30) or neither medication (n = 17) after aortic occlusion clamp release and for 24 hours postoperatively. Myocardial ischemic episodes (MIE) were considered to have occurred with ST-segment depressions or elevations of at least 1 mm and at least 2 mm (for both depressions or elevations), each at J + 60 ms and lasting at least 1 minute, using a two-channel Holter monitor. Results . Only nicardipine significantly decreased the duration ( p = 0.02) of the 1-mm or greater minutes per hour (3.2 ± 1.2 minutes per hour) and eliminated the number ( p = 0.02) of the 2-mm or greater minutes per hour (zero minutes per hour) when compared with control patients (17.2 ± 5.6 minutes per hour and 0.17 minutes per hour, respectively) during the intraoperative postbypass period. Conclusions . Our results suggest that nicardipine lessened the severity of myocardial ischemia shortly after coronary revascularization and could be considered as an alternative to standard antiischemic therapy. |
| Databáze: | OpenAIRE |
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