Imaging High-Risk Atherosclerotic Plaques with PET
| Autor: | Shawnbir Gogia, Ahmed Tawakol, Yannick Kaiser |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Underlying cause of death Atherosclerotic disease Inflammation 030204 cardiovascular system & hematology medicine.disease 03 medical and health sciences 0302 clinical medicine Positron emission tomography medicine 030212 general & internal medicine Radiology Myocardial infarction medicine.symptom Cardiology and Cardiovascular Medicine business Active inflammation Stroke Clinical risk factor |
| Zdroj: | Current treatment options in cardiovascular medicine. 18(12) |
| ISSN: | 1092-8464 |
| Popis: | Atherosclerotic disease, a primary cause of stroke and myocardial infarction, is the most common underlying cause of death worldwide. While atherosclerosis was formerly considered to be a relatively inert structural abnormality, decades of research have since shown that it is a biologically active process, driven by active inflammation. In concert with this conceptual shift, newer strategies to image vascular lesions have evolved. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging has been validated as a non-invasive tool to characterize atherosclerotic inflammation. It is hypothesized that a combination of structural and biological (e.g., inflammatory) imaging may provide better means to assess clinical risk, to assess efficacy of therapy, and to identify new, effective treatments. Limitations remain, however, and further advances in technology and tracer development are required before FDG PET imaging will contribute a significant clinical impact at the level of the individual patient. |
| Databáze: | OpenAIRE |
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