Zinc Supplements Taken with Food Increase Essential Fatty Acid Desaturation Indices in Adult Men Compared with Zinc Taken in the Fasted State
| Autor: | Jung H. Suh, Andrew G. Hall, Janet C. King, Yasaman N Massih |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine FADS1 Medicine (miscellaneous) chemistry.chemical_element 030209 endocrinology & metabolism Zinc 03 medical and health sciences 0302 clinical medicine Animal science Essential fatty acid Tandem Mass Spectrometry Humans Medicine chemistry.chemical_classification 030109 nutrition & dietetics Nutrition and Dietetics Fatty Acids Essential biology business.industry Fasting Metabolism Fatty acid desaturase Before Breakfast chemistry Fasted state Dietary Supplements biology.protein business Chromatography Liquid Zinc Supplements |
| Zdroj: | The Journal of Nutrition. 151:2583-2589 |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/nxab149 |
| Popis: | BACKGROUND Zinc intake is associated with reduced risk of metabolic disease in adults, possibly due in part to zinc's role in essential fatty acid (EFA) desaturation. Although plasma zinc is the accepted indicator of zinc status, product-to-precursor activity indices of fatty acid desaturase (FADS) 1 and 2 have also been proposed as response indicators for changes in zinc intake. OBJECTIVES To examine zinc supplement effects on plasma zinc concentration (PZC) and estimated FADS 1 and 2 activities, when zinc supplements are taken with food compared with fasted. METHODS Apparently healthy adult men were randomly allocated to take 25 mg zinc as zinc gluconate either in the fasted state 30 min before breakfast [zinc before breakfast (ZBB)] or with breakfast [zinc with breakfast (ZWB)] daily for 13 d. Fasting PZC was measured by inductively coupled plasma optical emission spectrometry. Selected EFAs for FADS activity indices were measured by LC-MS/MS at study baseline and end. RESULTS A total of 35 men completed the study (ZBB, n = 18; ZWB, n = 17). Mean ± SEM PZC was 86.2 ± 1.64 μg/dL at baseline. After 2 wk of zinc supplementation, the PZCs were 18% higher in the ZBB compared with the ZWB groups (105 ± 5.88 compared with 88.7 ± 2.36 μg/dL, P = < 0.05). However, the geometric mean (95% CI) FADS1 activity indices were 15% higher in the ZWB than the ZBB participants, 6.45 (5.84, 7.13) compared with 5.57 (5.05, 6.14), P |
| Databáze: | OpenAIRE |
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