The psychopharmacology of aggressive behavior: a translational approach: part 2: clinical studies using atypical antipsychotics, anticonvulsants, and lithium
| Autor: | Stefano Comai, Gabriella Gobbi, Michael Tau, Zoran M Pavlovic |
|---|---|
| Přispěvatelé: | Comai, Stefano, Tau, M, Pavlovic, Z, Gobbi, G. |
| Rok vydání: | 2012 |
| Předmět: |
Olanzapine
Psychopharmacology Loxapine Lithium Bioinformatics Atypical antipsychotics Translational Research Biomedical medicine Animals Humans Pharmacology (medical) Ziprasidone Amisulpride Clozapine Risperidone business.industry Mental Disorders Neurotransmitters Aggression Psychiatry and Mental health Anticonvulsants Translational medicine Lithium Compounds Quetiapine Aripiprazole business medicine.drug Antipsychotic Agents |
| Zdroj: | Journal of clinical psychopharmacology. 32(2) |
| ISSN: | 1533-712X |
| Popis: | Patients experiencing mental disorders are at an elevated risk for developing aggressive behavior. In the past 10 years, the psychopharmacological treatment of aggression has changed dramatically owing to the introduction of atypical antipsychotics on the market and the increased use of anticonvulsants and lithium in the treatment of aggressive patients.This review (second of 2 parts) uses a translational medicine approach to examine the neurobiology of aggression, discussing the major neurotransmitter systems implicated in its pathogenesis (serotonin, glutamate, norepinephrine, dopamine, and γ-aminobutyric acid) and the neuropharmacological rationale for using atypical antipsychotics, anticonvulsants, and lithium in the therapeutics of aggressive behavior. A critical review of all clinical trials using atypical antipsychotics (aripiprazole, clozapine, loxapine, olanzapine, quetiapine, risperidone, ziprasidone, and amisulpride), anticonvulsants (topiramate, valproate, lamotrigine, and gabapentin), and lithium are presented. Given the complex, multifaceted nature of aggression, a multifunctional combined therapy, targeting different receptors, seems to be the best strategy for treating aggressive behavior. This therapeutic strategy is supported by translational studies and a few human studies, even if additional randomized, double-blind, clinical trials are needed to confirm the clinical efficacy of this framework. |
| Databáze: | OpenAIRE |
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