The use of atypical antipsychotics in French psychiatric hospitals
| Autor: | Annie Fourier-Réglat, Marie Christine Bret, Antoine Pariente, Pierre Bret |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Hospitals Psychiatric Male medicine.medical_specialty Bipolar Disorder genetic structures medicine.drug_class Pharmaceutical Science Atypical antipsychotic Pharmacy Toxicology Antiparkinson Agents Benzodiazepines Sex Factors Antimanic Agents medicine Humans Pharmacology (medical) Hospital pharmacy Practice Patterns Physicians' Psychiatry Clozapine Pharmacology Dose-Response Relationship Drug business.industry Mental Disorders Age Factors General Medicine Middle Aged Risperidone Cross-Sectional Studies Psychotic Disorders Olanzapine Drug Therapy Combination Female France Amisulpride Sulpiride business Antipsychotic Agents |
| Zdroj: | Pharmacy worldscience : PWS. 29(5) |
| ISSN: | 0928-1231 |
| Popis: | To study the prescribing practices of atypical antipsychotic drugs in French psychiatric hospitals.A 1-day cross-sectional observational survey was performed in seven psychiatric hospitals to study prescribing practices of the four atypical antipsychotics (AAP) marketed in France. These hospitals are members of the PIC network, a pharmacists' working group based in southwestern France.Type and dosages of prescribed atypical antipsychotics, indication and concomitant prescriptions.The study included 1475 adult inpatients' prescriptions with an antipsychotic drug; 647 prescriptions included an AAP with risperidone and olanzapine accounting for about 70% cases. AAP prescriptions concerned psychotic patients in 65% of cases. Patients receiving an AAP in this indication were more likely to be male, were younger, and received higher daily doses than patients treated for other troubles. They were also more likely to receive associated neuroleptic and anticholinergic antiparkinsonian agents. There were 59 prescriptions (9.1%) for bipolar disorders. Clozapine wasn't used in this indication. In 76.3% of cases, mood stabilizers were associated to the AAP prescribed in this indication.This observational survey underlines the significant place taken by AAP for the treatment of psychiatric diseases in hospital prescribing practices. They show usage patterns of these drugs: dose, indications and concomitant medications, in line or not with current recommendations and reference guidelines. In bipolar disorders, AAPs seem more likely to be associated to an ongoing therapy using mood stabilizer than to replace it. |
| Databáze: | OpenAIRE |
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