Effects of icariin on ovarian function in d-galactose-induced aging mice
| Autor: | Di Zhen, Jian-Ming Gao, Xin-Mei Wang, Jun-Li Wang, Xiao-Meng Huang, Bing Liu, Chao Zhang, Wu Chen |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Anti-Mullerian Hormone
Male Aging endocrine system medicine.medical_specialty Serum fsh Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ovarian function Food Animals Internal medicine medicine Animals Small Animals bcl-2-Associated X Protein Flavonoids 030219 obstetrics & reproductive medicine Equine Ovary 0402 animal and dairy science Galactose 04 agricultural and veterinary sciences 040201 dairy & animal science Specific Pathogen-Free Organisms Blot Endocrinology Gene Expression Regulation Proto-Oncogene Proteins c-bcl-2 chemistry Female Animal Science and Zoology Icariin |
| Zdroj: | Theriogenology. 125:157-167 |
| ISSN: | 0093-691X |
| DOI: | 10.1016/j.theriogenology.2018.10.028 |
| Popis: | In this study, effects of icariin (Ica) on were examined in a mouse model of d -galactose (D-gal)-induced ovarian aging. Kunming white mice were divided into three groups: aging group induced with D-gal, experiment group treated with Ica at low (50 mg/kg), middle (100 mg/kg) and high (200 mg/kg) concentrations, and control group with no treatment. Ovarian histomorphology, serum FSH, LH and E2 levels, and reproductive function were compared among the groups. Ovarian expression of Amh, Bax and Bcl-2 was examined by qPCR and western blotting. Our results showed that diameters of secondary and tertiary follicles were significantly reduced in the aging group when compared with control group (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect