Ginger Water Reduces Body Weight Gain and Improves Energy Expenditure in Rats
| Autor: | Saqer S. Alotaibi, Ahmed M. El-Shehawi, Hanan B. El-Sawy, Mohamed M. Ahmed, Mohamed Alkafafy, Samir A. El-Shazly, Samy Sayed, Samy Farouk |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
obesity Health (social science) Adipose tissue Plant Science lcsh:Chemical technology Health Professions (miscellaneous) Microbiology Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine lcsh:TP1-1185 rat Carnitine energy homeostasis 030304 developmental biology 0303 health sciences Adiponectin Chemistry Leptin Lipid metabolism ginger water Galangin Endocrinology 030220 oncology & carcinogenesis gene expression Pyruvate kinase Food Science Average Body Weight Gain medicine.drug |
| Zdroj: | Foods Volume 9 Issue 1 Foods, Vol 9, Iss 1, p 38 (2020) |
| ISSN: | 2304-8158 |
| Popis: | Obesity is a serious global problem that causes predisposition to numerous serious diseases. The current study aims to investigate the effect of ginger water on body weight and energy expenditure through modulation of mRNA expression of carbohydrate and lipid metabolism. A white colored liquid obtained during freeze-drying of fresh rhizomes of Zingiber officinal was collected and named ginger water. It was used to treat rats, then blood and tissue samples were collected from the liver and white adipose at the end of the experiment. The serum was prepared and used for biochemical assays, while tissue samples were used for RNA isolation and gene expression analysis via RT-PCR. Results of High Performance Liquid Chromatography (HPLC) analysis of ginger water revealed the presence of chrysin and galangin at concentrations of 0.24 µ g/mL and 0.53 µ g/mL, respectively. Average body weight gain decreased significantly in groups that received ginger water. In addition, both total cholesterol and serum triacylglycerol were reduced in the groups that received ginger water. Furthermore, mRNA expression of Sterol regulatory element-binding protein 1 (SREBP-1c) in the liver and leptin in adipose tissues were downregulated, while those of adiponectin, hepatic carnitine palmitoyltransferase1 (CPT-1), acyl-coA oxidase (ACO), Glucose transporter 2 (GLUT-2), and pyruvate kinase (PK) were upregulated in ginger water-treated groups. These results clearly revealed the lowering body weight gain effect of ginger water, which most likely occurs at the transcriptional level of energy metabolizing proteins. |
| Databáze: | OpenAIRE |
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