Drug induced micellization into ultra-high capacity and stable curcumin nanoformulations: Physico-chemical characterization and evaluation in 2D and 3D in vitro models
| Autor: | Julia Seifert, Johanna Kühnemundt, Gudrun Dandekar, Lena C. Nelke, Sarah Nietzer, Robert Luxenhofer, Michael M. Lübtow, Gaurav Sahay |
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| Přispěvatelé: | Publica |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Drug
Curcumin Cell Survival Swine media_common.quotation_subject Pharmaceutical Science Antineoplastic Agents 02 engineering and technology Health benefits Cell Line feste amorphe Dispersion 03 medical and health sciences chemistry.chemical_compound Animals Humans Curcuma Micelles Poly (2-oxazolin) 030304 developmental biology media_common Poly (2-oxazin) Drug Carriers 0303 health sciences Traditional medicine biology Chemistry 3D-Tumormodell High loading High capacity 021001 nanoscience & nanotechnology biology.organism_classification Nanomedizin Drug delivery Nanoparticles Colorectal Neoplasms 0210 nano-technology |
| Popis: | Curcumin (CUR)is a natural extract from the plant Curcuma longa and part of turmeric, a spice and herbal remedy in traditional medicine. Thousands of papers claim a plethora of health benefits by CUR, but a growing number of reports and contributions caution that many experimental data may be artifacts or outright deny any suitability of CUR due to its problematic physicochemical properties. Two major issues often encountered with CUR are its extraordinarily low solubility in water and its limited chemical stability. Here, we report on a novel nanoformulation of CUR that enables CUR concentrations in water of at least 50 g/L with relative drug loadings of >50 wt% and high dose efficacy testing in 3D tumor models. Despite this high loading and concentration, the CUR nanoformulation comprises polymer-drug aggregates with a size |
| Databáze: | OpenAIRE |
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