Postprandial hypotension: hemodynamic differences between multiple system atrophy and peripheral autonomic neuropathy
| Autor: | Akira Takahashi, Nobuo Sakurai, Masaaki Hirayama, Shigetaka Hakusui, Y. Kanaoke, Y. Hasegawa, Yasuo Koike, Hidetsugu Watanabe |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Cardiac output Physiology Administration Oral Hemodynamics Eating Internal medicine Heart rate medicine Humans Ingestion Hereditary Sensory and Autonomic Neuropathies business.industry General Neuroscience Middle Aged medicine.disease Vasodilation Glucose Peripheral neuropathy Blood pressure Endocrinology Postprandial medicine.anatomical_structure Vascular resistance Cardiology Female Neurology (clinical) Hypotension business |
| Zdroj: | ResearcherID |
| ISSN: | 0165-1838 |
| DOI: | 10.1016/0165-1838(93)90315-l |
| Popis: | To clarify the mechanism of postprandial hypotension (PPH), we performed hemodynamic investigation after oral glucose ingestion in ten patients with multiple system atrophy (MSA), three patients with peripheral autonomic neuropathy (PN) and 16 normal controls. Blood pressure (BP) and heart rate (HR) were measured with an automatic sphygmomanometer; cardiac out (CO) and lower leg blood flow (LBF) with impedance plethysmography; and portal blood flow (PBF) using a B-mode pulse Doppler. In normal subjects, BP, LBF and vascular resistance of the lower leg (LVR) were not changed, but HR slightly increased, and PBF and CO significantly increased after oral ingestion of 75 g glucose. In the patients with MSA, BP fell significantly 15 min after glucose ingestion, and HR and CO did not increase. PBF and LBF increased and LVR fell significantly. In PN patients, BP decreased at 15 min after glucose ingestion, but soon recovered. Increase of PBF and decrease of LVR in them were almost similar to those in the MSA group, and increase of CO was greater than that in the controls. These results suggest that both systemic vasodilatation (presumably due to gastrointestinal vasodilatatory peptides) and lack of compensatory increase of CO and LVR play important roles in PPH. |
| Databáze: | OpenAIRE |
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