Nulidade de GSTT1/GSTM1 relacionada a pesticidas associa-se com doenca de Parkinson

Autor: Marcelo Arruda Nakazone, Gisele S. Amorim, Camila M. Mazeti, Waldir Antonio Tognola, Michele Lima Gregório, Caroline L. Sado, Marcela Augusta de Souza Pinhel, Denise P. Martins, Dorotéia Rossi Silva Souza, Greiciane Maria da Silva Florim, Fabio de Nazare Oliveira, Gabriela S. Longo
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Male
Parkinson's disease
Genotype
Disease
Polymerase Chain Reaction
xenobioticos
Developmental psychology
law.invention
lcsh:RC321-571
Pathogenesis
chemistry.chemical_compound
law
Risk Factors
glutathione transferase
Medicine
Humans
xenobiotics
Genetic Predisposition to Disease
glutationa transferase
Pesticides
polimorfismo genetico
neoplasms
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Polymerase chain reaction
Aged
Glutathione Transferase
chemistry.chemical_classification
Polymorphism
Genetic
integumentary system
business.industry
polymorphism genetic
Parkinson Disease
Glutathione
Pesticide
medicine.disease
Parkinson disease
Exact test
Enzyme
Neurology
chemistry
Case-Control Studies
Immunology
doenca de Parkinson
Female
Gene-Environment Interaction
Neurology (clinical)
business
Zdroj: Arquivos de Neuro-Psiquiatria, Vol 71, Iss 8, Pp 527-532 (2013)
Arquivos de Neuro-Psiquiatria v.71 n.8 2013
Arquivos de neuro-psiquiatria
Academia Brasileira de Neurologia
instacron:ABNEURO
Arquivos de Neuro-Psiquiatria, Volume: 71, Issue: 8, Pages: 527-532, Published: AUG 2013
ISSN: 1678-4227
Popis: Genetic and environmental factors affect the pathogenesis of Parkinson's disease (PD). Genetic variants of the enzyme glutathione S-transferases (GST) may be related to the disease. This study aimed to evaluate the influence of genetic variants of GST (GSTT1/GSTM1) and their association with the exposure to environmental toxins in PD patients. We studied 254 patients with PD and 169 controls. The GSTM1/GSTT1 variants were analyzed by polymerase chain reaction. We applied the Fisher's exact test and the χ2 test for statistical analysis (p
Databáze: OpenAIRE
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