A Model of Human Tumor Dormancy: An Angiogenic Switch From the Nonangiogenic Phenotype
| Autor: | Lars A. Akslen, Evelyn Flynn, George N. Naumov, David A. Sampson, Randolph S. Watnick, Oddbjørn Straume, Elise Bender, Judah Folkman, David Zurakowski, Soo-Young Kang, Nava Almog |
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| Rok vydání: | 2006 |
| Předmět: |
Vascular Endothelial Growth Factor A
Cancer Research Pathology medicine.medical_specialty Time Factors Angiogenic Switch Angiogenesis Immunoblotting Enzyme-Linked Immunosorbent Assay Mice SCID Adenocarcinoma Biology Thrombospondin 1 Neovascularization Mice Cell Line Tumor In Situ Nick-End Labeling Tumor Cells Cultured medicine Animals Humans Cell Proliferation Osteosarcoma Neovascularization Pathologic Cancer medicine.disease Immunohistochemistry Angiogenesis inhibitor Gene Expression Regulation Neoplastic Phenotype Oncology Tumor progression Fibroblast Growth Factor 2 medicine.symptom Glioblastoma |
| Zdroj: | JNCI: Journal of the National Cancer Institute. 98:316-325 |
| ISSN: | 1460-2105 0027-8874 |
| Popis: | Background: Microscopic human cancers can remain dormant for life . Tumor progression depends on sequential events, including a switch to the angiogenic phenotype, i.e., initial recruitment of new vessels . We previously demonstrated that human tumors contain tumor cell populations that are heterogeneous in angiogenic activity. Here, we separated angiogenic from nonangiogenic human tumor cell populations and compared their growth. Methods: Severe combined immunodefi cient (SCID) mice were inoculated with nonangiogenic human MDA-MB-436 breast adenocarcinoma, KHOS-24OS osteosarcoma, or T98G glioblastoma cells. Most of the resulting tumors remained microscopic ( |
| Databáze: | OpenAIRE |
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