Non-invasive imaging of single human motor units
| Autor: | MG Birkbeck, Linda Heskamp, Andrew M. Blamire, Roger G. Whittaker, Ian S. Schofield |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
CSA Cross Sectional Area TE Echo Time TA Tibialis Anterior Electromyography MU Motor Unit 0302 clinical medicine FOV Field Of View Medicine Aged 80 and over Motor Neurons medicine.diagnostic_test Motor unit 05 social sciences Middle Aged Maximum dimension Magnetic Resonance Imaging MUMRI Motor Unit Magnetic Resonance Imaging Sensory Systems Alternation TR Repetition Time Neurology Female PL Peroneus Longus Recruitment Neurophysiological Adult Noninvasive imaging GL Gastrocnemius Lateralis SOL Soleus Article MRI Magnetic Resonance Imaging 050105 experimental psychology 03 medical and health sciences Motor unit morphology Physiology (medical) Humans 0501 psychology and cognitive sciences EMG Electromyography Muscle Skeletal Aged ROI Region Of Interest EDL Extensor Digitorum Longus business.industry Disease progression Diffusion weighted imaging Magnetic resonance imaging Diffusion Magnetic Resonance Imaging GM Gastrocnemius Medialis Neurology (clinical) business 030217 neurology & neurosurgery Diffusion MRI Biomedical engineering |
| Zdroj: | Clinical Neurophysiology |
| ISSN: | 1388-2457 |
| DOI: | 10.1016/j.clinph.2020.02.004 |
| Popis: | Highlights • A novel MRI technique capable of detecting the size, shape and distribution of human motor units is described. • Human motor units have a range of different outlines including elliptical, complex or split. • This technique demonstrates a heterogeneous remodelling of motor units with age. Objective To determine the size, shape and distribution of single human motor units in-vivo in healthy controls of different ages. Methods A novel diffusion-weighted magnetic resonance imaging (MRI) technique was used in combination with in-scanner electrical stimulation to quantify the shape, cross-sectional area, and dimensions of individual motor units in 10 healthy subjects. Results Thirty-one discrete motor units were studied. The majority were elliptical or crescent shaped, but occasional split motor units were observed. The mean motor unit cross sectional area was 26.7 ± 11.2 mm2, the mean maximum dimension was 10.7 ± 3.3 mm, and the mean minimum dimension was 4.5 ± 1.2 mm. Subjects aged over 40 had significantly larger maximum dimensions than those below this age (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect