Trastuzumab in the treatment of advanced breast cancer: Single-center experience
| Autor: | Boris Labar, Z. Budišić, Mirando Mrsić, M. Gošev, Vinko Bogdanić, N. Restek-Samaržija, Jasminka Jakić-Razumović, P. Podolski, M. Grgić |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Croatia Receptor ErbB-2 medicine.medical_treatment Antineoplastic Agents Breast Neoplasms Antibodies Monoclonal Humanized Severity of Illness Index Hospitals University Breast cancer Trastuzumab Internal medicine Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor medicine Humans skin and connective tissue diseases Chemotherapy business.industry Antibodies Monoclonal Cancer Hematology Middle Aged medicine.disease Chemotherapy regimen Metastatic breast cancer Gemcitabine Surgery Treatment Outcome Female business Febrile neutropenia medicine.drug |
| Zdroj: | Annals of Oncology. 12:S95-S96 |
| ISSN: | 0923-7534 |
| DOI: | 10.1093/annonc/12.suppl_1.s95 |
| Popis: | A significant number of women with advanced breast cancer fail to respond to standard-dose chemotherapy. From the beginning of 1999, 17 women with HER2 positive advanced breast cancer received Herceptin as monotherapy or in combination with paclitaxel or other non-anthracyclines. Eight (47%) women previously received high-dose chemotherapy followed by haematopoiesis stem cell rescue. Three women received Herceptin alone, eleven Herceptin plus paclitaxel and three Herceptin and some of the other non-anthracyclines (CCNU, cisplatin and gemcitabine). In the group of patients who received Herceptin monotherapy, one has partial response (PR), one stable disease (SD) and in the third patient the disease progressed. Out of three patients who received Herceptin in combination with other non-anthracyclines, two have SD and one progressed. In the group of 11 women who received Herceptin + Taxol, 7 (64%) patients achieved PR, 2 (18%) SD, and 2 (18%) had disease progression. Grade 3-4 neutropenia has been observed in four (23%) women. Febrile neutropenia was observed in two cases and resolved completely when antibiotics were introduced. Other grade 3 toxicity that has been noted is peripheral neuropathy in three (18%) patients, diarrhoea in four (23%) and onycholysis in one (6%). Serial heart ultrasound showed no significant decline in left ventricular ejection fraction. According to our preliminary experience, Herceptin therapy showed promising results in women with metastatic breast cancer. |
| Databáze: | OpenAIRE |
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