Cellular aspects of gonadal atrophy in Drosophila P-M hybrid dysgenesis
| Autor: | E. U. Bolobolova, L. P. Zakharenko, N. V. Dorogova |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male endocrine system Programmed cell death medicine.medical_specialty Gonad Sterility Biology 03 medical and health sciences Dysgenesis 0302 clinical medicine Internal medicine medicine Animals Gonads Molecular Biology Embryogenesis Temperature Cell Biology biology.organism_classification Cell biology Mitochondria 030104 developmental biology medicine.anatomical_structure Endocrinology Drosophila melanogaster Germ Cells Phenotype Hybridization Genetic Female Germ line development Atrophy 030217 neurology & neurosurgery Germ cell Developmental Biology |
| Zdroj: | Developmental biology. 424(2) |
| ISSN: | 1095-564X |
| Popis: | Gonadal atrophy is the most typical and dramatic manifestation of intraspecific hybrid dysgenesis syndrome leading to sterility in Drosophila melanogaster dysgenic progeny. The P-M system of hybrid dysgenesis is primarily associated with germ cell degeneration during the early stages of Drosophila embryonic development at elevated temperatures. In the present study, we have defined the phase of germ cell death as beginning at the end of embryogenesis immediately following gonad formation. However, the temperature-dependent screening of germ cell developmental patterns in the dysgenic background showed that early germ cells are susceptible to the hybrid dysgenesis at any Drosophila life-cycle stage, including in the imago. Electron microscopy of germ cells after dysgenesis induction revealed significant changes in subcellular structure, especially mitochondria, prior to cellular breakdown. The mitochondrial pathology can promote the activation of cell death pathways in dysgenic germ cells, which leads to gonadal atrophy. |
| Databáze: | OpenAIRE |
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