Efeito de enemas contendo budesonida e probióticos na resposta inflamatória sistêmica de ratos com colite experimental
| Autor: | Diana Borges Dock-Nascimento, José Eduardo de Aguilar-Nascimento, Mardem Machado de Souza |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Budesonide
Male medicine.medical_treatment Anti-Inflammatory Agents Drug Evaluation Preclinical Gastroenterology law.invention Probiotic Random Allocation law Medicine Budesonida Saline Ratos biology Enema Ulcerative colitis Systemic Inflammatory Response Syndrome Colite ulcerative C-Reactive Protein Acute Disease medicine.drug medicine.medical_specialty Colon Mucosa Internal medicine Animals Colitis Rats Wistar Interleukin 6 Serum Albumin Proteina C reativa IL-6 business.industry Interleukin-6 Probiotics Body Weight Albumin Probióticos medicine.disease Rats Disease Models Animal biology.protein Surgery Colitis Ulcerative business Acute-Phase Proteins |
| Zdroj: | Acta Cirurgica Brasileira, Volume: 22 Supplement 1, Pages: 40-45, Published: 2007 Acta Cirúrgica Brasileira v.22 suppl.1 2007 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
| Popis: | PURPOSE: The aim of this study was to investigate the effect of enemas containing probiotics and budesonide on the systemic inflammatory response in experimental colitis. METHODS: Fifty male Wistar rats with experimental colitis induced by 10% acetic acid enema were randomized to five groups (10 rats each) according to the treatment: group 1 - saline solution, group 2 - budesonide (0.75 mg/kg/day), group 3 - probiotics (1mg/day), group 4 - probiotics plus budesonide, and group 5 - control, with not-treated rats. The following variables were studied: body weight, serum levels of albumin, C-reactive protein and interleucine-6 (IL-6). RESULTS: All animals lost weight between the beginning and the end of the experiment (280+ 16 mg versus 249+21 mg, p< 0.001). There was a significant decrease in the serum albumin between the normal pre-induction level (3.45 + 0.49mg/dL) and the 1st day after colitis induction (1.61+051mg/dL, p< 0.001) in all treated groups when compared to the control group. C- reactive protein increased after induction and diminished on the 7th day in all groups. In the control group there was an increase in the IL-6 after colitis induction. None of the treated groups significantly differed from IL-6 pre-colitis status (p>0.05). Only probiotic rats presented a significant decrease of IL-6 than controls (0,30±0,08 mg/dL vs. 0,19±0,03 mg/dL; p0.05). As comparações entre o grupo controle (0,30±0,08 mg/dL) e outros mostraram que houve uma queda significante nos níveis de IL-6 apenas no grupo probiótico (0,19±0,03 mg/dL; p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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