Prevalence, burden and treatment effects of vaginal bleeding in women with (suspected) congenital platelet disorders throughout life: a cross-sectional study
| Autor: | Punt, Marieke C., Ruigrok, Nienke D., Bloemenkamp, Kitty W.M., Uitslager, Nanda, Urbanus, Rolf T., Groot, Evelyn, Kremer Hovinga, Idske C.L., Schutgens, R. E.G., van Galen, K. P.M., Kruip, M. J.H.A., Beckers, E. A.M., Coppens, M., Eikenboom, J., Tamminga, R. Y.J. |
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| Přispěvatelé: | Hematology, Pediatrics |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Adult
medicine.medical_specialty Platelet disorder Miscarriage Menstruation Quality of life Cost of Illness Surveys and Questionnaires medicine Prevalence Humans Vaginal bleeding Public Health Surveillance Age of Onset Menorrhagia Netherlands Pregnancy business.industry Obstetrics Disease Management Hematology Middle Aged medicine.disease Cross-Sectional Studies Treatment Outcome Cohort Menarche Quality of Life Female Blood Platelet Disorders Disease Susceptibility Uterine Hemorrhage medicine.symptom business |
| Zdroj: | British Journal of Haematology, 196(1), 215-223. Wiley-Blackwell Publishing Ltd |
| ISSN: | 0007-1048 |
| Popis: | Congenital platelet disorders (CPDs) are rare bleeding disorders that are associated with mucocutaneous bleeds. However, data on vaginal bleeding in women with CPDs are scarce. A set of generic and bleeding-specific questionnaires were used to evaluate the prevalence of vaginal bleeding, its impact on quality of life (QoL) and sexual functioning and the consequences for pregnancy, miscarriage and delivery in a cohort of women who were referred for diagnostic evaluation for CPDs. A total of 78 women included in the study were either diagnosed with a CPD (n = 35) or were clinically suspected of a CPD (n = 43). Heavy menstrual bleeding (HMB) was reported by a large proportion of women, which mainly started at menarche. In all, 76% of women received any kind of HMB treatment, often leading to surgical prodecures. HMB was shown to have a high impact on QoL, which improved upon treatment. Even though women reported that vaginal bleeding affects sexuality, this topic is not frequently discussed with physicians. Heavy blood loss frequently occurred after miscarriage/delivery, often requiring treatment. Women with (suspected) CPDs frequently encounter HMB, negatively impacting daily life and sexual functioning. Together with peripartum bleeding, these data highlight the burden of vaginal bleeding in CPDs and importance of adequate treatment. |
| Databáze: | OpenAIRE |
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