COVID-19-associated pulmonary aspergillosis in a Japanese man: A case report

Autor: Koichi Yamada, Kenji Matsuo, Hoshi Himura, Tetsuro Nishimura, Ayako Kiritoshi, Sae Kawata, Masahiro Miyashita, Tomohiro Noda, Waki Imoto, Yasumitsu Mizobata, Hiroshi Kakeya, Kenichiro Uchida, K Yamamoto, Hiromasa Yamamoto, Ryo Deguchi, Shinichiro Kaga
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
Microbiology (medical)
medicine.medical_specialty
medicine.medical_treatment
030106 microbiology
Case Report
Invasive pulmonary aspergillosis
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2

Aspergillus fumigatus
03 medical and health sciences
0302 clinical medicine
AZM
azithromycin

IPA
invasive pulmonary aspergillosis

Internal medicine
medicine
DEXA
dexamethasone

Pharmacology (medical)
030212 general & internal medicine
Dexamethasone
ARDS
acute respiratory distress syndrome

COVID-19
coronavirus disease

Voriconazole
Mechanical ventilation
Lung
CAPA
COVID-19 associated pulmonary aspergillosis

biology
business.industry
Incidence (epidemiology)
biology.organism_classification
Coronavirus disease
CT
computed tomography

Infectious Diseases
medicine.anatomical_structure
COVID-19-Associated pulmonary aspergillosis
COPD
chronic obstructive pulmonary disease

Sputum
BAL
bronchoalveolar lavage

medicine.symptom
Complication
business
medicine.drug
Zdroj: Journal of Infection and Chemotherapy
ISSN: 1437-7780
1341-321X
Popis: CAPA (COVID-19 associated pulmonary aspergillosis) is an important complication of COVID-19. It has been reported that the incidence of CAPA is as high as 19%-33% worldwide. However, its onset has not been reported in Japan. A 72-year-old Japanese man was diagnosed with COVID-19 and was transferred to our hospital due to deterioration of respiratory condition. Treatment with remdesivir, dexamethasone (DEXA), and antibiotics was performed under mechanical ventilation. Although the condition improved temporarily, a new shadow appeared in the lung, and Aspergillus fumigatus was cultured from sputum. The patient was clinically diagnosed with CAPA and treated with voriconazole. However, his progress deteriorated and he died. High-risk COVID-19 patients should be tested for Aspergillus to ensure early diagnosis of CAPA.
Databáze: OpenAIRE