Preparation of a Cage-Type Polyglycolic Acid/Collagen Nanofiber Blend with Improved Surface Wettability and Handling Properties for Potential Biomedical Applications
| Autor: | Ick Soo Kim, Hisatoshi Kobayashi, Shunichi Kobayashi, Sheeraz Khan Mahar, Duy-Nam Phan, Zeeshan Khatri, Muzamil Khatri, Sofia El-Ghazali |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Morphology (linguistics) Polymers and Plastics ozonation Organic chemistry General Chemistry handling properties Electrospinning Article electrospinning nanofiber blend surface modification plasma treatment cage-type collector symbols.namesake QD241-441 Tissue engineering Chemical engineering Nanofiber symbols Surface modification Wetting Fourier transform infrared spectroscopy Raman spectroscopy |
| Zdroj: | Polymers, Vol 13, Iss 3458, p 3458 (2021) Polymers; Volume 13; Issue 20; Pages: 3458 Polymers |
| ISSN: | 2073-4360 |
| Popis: | Electrospun biobased polymeric nanofiber blends are widely used as biomaterials for different applications, such as tissue engineering and cell adhesion; however, their surface wettability and handling require further improvements for their practical utilization in the assistance of surgical operations. Therefore, Polyglycolic acid (PGA) and collagen-based nanofibers with three different ratios (40:60, 50:50 and 60:40) were prepared using the electrospinning method, and their surface wettability was improved using ozonation and plasma (nitrogen) treatment. The effect on the wettability and the morphology of pristine and blended PGA and collagen nanofibers was assessed using the WCA test and SEM, respectively. It was observed that PGA/collagen with the ratio 60:40 was the optimal blend, which resulted in nanofibers with easy handling and bead-free morphology that could maintain their structural integrity even after the surface treatments, imparting hydrophilicity on the surface, which can be advantageous for cell adhesion applications. Additionally, a cage-type collector was used during the electrospinning process to provide better handling properties to (PGA/collagen 60:40) blend. The resultant nanofiber mat was then incorporated with activated poly (α,β-malic acid) to improve its surface hydrophilicity. The chemical composition of PGA/collagen 60:40 was assessed using FTIR spectroscopy, supported by Raman spectroscopy. |
| Databáze: | OpenAIRE |
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