Effects of grape seed extract on periodontal disease: an experimental study in rats
| Autor: | Umur Sakallioğlu, Feyza Otan Özden, Bulent Ayas, Elif Eser Sakallioğlu, Zuleyha Erisgin |
|---|---|
| Přispěvatelé: | Fakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı, Erişgin, Züleyha, OMÜ |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Molar Pathology Time Factors TGR-beta medicine.medical_treatment Anti-Inflammatory Agents Gingiva Gastroenterology Antioxidants Group B Rats Sprague-Dawley Random Allocation 0302 clinical medicine Transforming Growth Factor beta Periodontal diseases Immunohistochemistry Interleukin-10 Treatment Outcome medicine.anatomical_structure Grape seed extract IL-10 Original Article TGF-β medicine.medical_specialty food.ingredient Connective tissue 03 medical and health sciences food TGR-Beta Internal medicine medicine Animals Periodontal fiber Periodontitis Ligature General Dentistry Periodontal Diseases Grape Seed Extract business.industry Reproducibility of Results 030206 dentistry medicine.disease Chronic periodontitis lcsh:RK1-715 030104 developmental biology lcsh:Dentistry Chronic Periodontitis business |
| Zdroj: | Journal of Applied Oral Science, Vol 25, Iss 2, Pp 121-129 Journal of Applied Oral Science, Volume: 25, Issue: 2, Pages: 121-129, Published: APR 2017 Journal of Applied Oral Science Journal of Applied Oral Science v.25 n.2 2017 Journal of applied oral science Universidade de São Paulo (USP) instacron:USP |
| Popis: | Sakallioglu, Umur/0000-0002-8823-755X WOS: 000399107700002 PubMed: 28403352 Natural compounds capable of modulating the host response have received considerable attention, and herbal products are suggested as adjunctive agents in periodontal disease treatment. Objective: This study aimed to demonstrate the effect of grape seed extract (GSE) on periodontitis. Material and Methods: Ligature induced periodontitis was created in 40 rats and they were assigned to four equal groups. One group was fed laboratory diet (group A) while three groups received GSE additionally. Silk ligatures were placed around the cervical area of the mandibular first molars for four weeks to induce periodontitis. The GSE groups were reallocated regarding GSE consumption as: for two weeks before ligation (group B; totally eight weeks), from ligation to two weeks after removal of the ligature (group C; totally six weeks), and for two weeks from ligature removal (group D; totally two weeks). Sections were assessed histologically and immunohistochemically. Inflammatory cell number (ICN), connective tissue attachment level (CAL), osteoclast density (OD), IL-10 and TGF-beta stainings in gingival epithelium (GE), connective tissue (GC), and periodontal ligament (PL) were used as the study parameters. Results: Lower ICN, higher CAL, and lower OD were observed in the GSE groups (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|