Effect of aging on neuroglobin expression in rodent brain
| Autor: | David A. Greenberg, Kunlin Jin, Yunjuan Sun, Xiaojuan Wang, Anna Logvinova, Jocelyn Childs, Lin Xie, Xiao Ou Mao, Alyson Peel |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Senescence Aging Cerebellum Pathology medicine.medical_specialty Hemeprotein Blotting Western Neuroglobin Nerve Tissue Proteins Biology Neuroprotection Mice Gene expression medicine Animals RNA Messenger Globin Regulation of gene expression Reverse Transcriptase Polymerase Chain Reaction General Neuroscience Age Factors Brain Blotting Northern Immunohistochemistry Globins medicine.anatomical_structure Gene Expression Regulation nervous system Neurology (clinical) Geriatrics and Gerontology Developmental Biology |
| Zdroj: | Neurobiology of Aging. 26:275-278 |
| ISSN: | 0197-4580 |
| Popis: | Neuroglobin (Ngb), a recently discovered O2-binding heme protein related to hemoglobin and myoglobin, protects neurons from hypoxic-ischemic injury in vitro and in vivo. In immunostained mouse brain sections, we found widespread expression of Ngb protein in neurons, but not astrocytes, of several brain regions that are prominently involved in age-related neurodegenerative disorders. Western blots from young adult (3 month), middle-aged (12 month), and aged (24 month) rats showed an age-related decline in Ngb expression in cerebral neocortex, hippocampus, caudate-putamen, and cerebellum. Loss of this neuroprotective protein may have a role in increasing susceptibility to age-related neurological disorders. |
| Databáze: | OpenAIRE |
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