Clinical Analysis of Patients with Sepsis-Comparison between Underlying Diseases
| Autor: | Toshimasa Majima, Keiichi Mikasa, Katsuhiro Ueda, Mitsuru Konishi, Masayoshi Sawaki, Takayuki Masutani, Masayuki Tsujimoto, Reiko Sano, Masahiro Sakamoto, Koichi Maeda, Mori K, Nobuhiro Narita, Teramoto S, Akira Koizumi |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Urinary system Gastroenterology Sepsis Neoplasms Internal medicine medicine Humans Blood culture Stomatitis Aged medicine.diagnostic_test Clinical pathology business.industry General Medicine Middle Aged Prognosis medicine.disease Pneumonia Shock (circulatory) Female medicine.symptom Coagulase business |
| Zdroj: | Journal of the Japanese Association for Infectious Diseases. 72:681-687 |
| ISSN: | 1884-569X 0387-5911 |
| Popis: | We evaluated the clinical data in 83 patients with sepsis, which was diagnosed by both Bone's definition of sepsis and positive isolates from blood culture, according to their underlying diseases. This study enrolled a total of 117 septic episodes in 83 patients (57 males and 26 females, mean age: 52.0 years). We classified 3 groups, including hematological malignancies (46 patients, 72 episodes), solid malignant tumors (23 patients, 25 episodes) and non-malignancies (14 patients, 20 episodes), by the underlying diseases. Of the total number of isolates from blood culture, 53.0% were single gram-positive bacteria, 33.3% were single gram-negative bacteria, 7.7% were single fungus and 6.0% were polymicrobial organisms. In addition, coagulase negative staphylococci was isolated most often in patients with hematological malignancies. Sepsis was often caused by infectious focuses of hemorrhoid, stomatitis or intravenous catheter in patients with hematological malignancies, by pneumonia in patients with solid malignant tumors and by urinary tract infection in patients with non-malignancies. Mortality of sepsis in patients with solid malignant tumors (48%) was highest in 3 groups. Septic patients, who were complicated with shock and/or DIC, has poor prognosis in all groups. Serum albumin level was significantly lower in dead patients than patients who survived. These results suggest that clinical features may be different according to the underlying diseases of patients with sepsis. |
| Databáze: | OpenAIRE |
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