Increased lysyl oxidase-like 2 associates with a poor prognosis in non-small cell lung cancer
| Autor: | Haiyan Xie, Ping Zhan, Xiao-Jing Lv, Ya-Nan Ji, Li-Ke Yu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Pulmonary and Respiratory Medicine Oncology medicine.medical_specialty Lung Neoplasms Lysyl oxidase Kaplan-Meier Estimate Risk Assessment Disease-Free Survival Statistics Nonparametric Metastasis 03 medical and health sciences 0302 clinical medicine Breast cancer Carcinoma Non-Small-Cell Lung Internal medicine medicine Humans Immunology and Allergy Stage (cooking) Pneumonectomy Lung cancer Genetics (clinical) Aged Lung LOXL2 business.industry Middle Aged Prognosis medicine.disease Survival Analysis Up-Regulation respiratory tract diseases Gene Expression Regulation Neoplastic Treatment Outcome 030104 developmental biology medicine.anatomical_structure Case-Control Studies 030220 oncology & carcinogenesis Adenocarcinoma Female Amino Acid Oxidoreductases business |
| Zdroj: | The Clinical Respiratory Journal. 12:712-720 |
| ISSN: | 1752-6981 |
| DOI: | 10.1111/crj.12584 |
| Popis: | Background: Lysyl oxidase-like 2 (LOXL2) is a member of the lysyl oxidase family and is associated with invasiveness and metastasis in breast cancer. However, its relevance in non-small cell lung cancer (NSCLC) remained largely unknown. Methods: LOXL2 protein levels in a cohort of NSCLC and adjacent normal lung tissues were evaluated and analyzed their clinicopathologic and prognostic significance. Results: We found that cytoplasmic and nuclear LOXL2 levels were higher in lung adenocarcinoma (AD) and squamous cell carcinoma (SCC) tissues than in paired adjacent normal tissues. High LOXL2 levels were associated with p-TNM stage, and cytoplasmic, but not nuclear, LOXL2 levels were an independent prognostic factor in lung AD and SCC patients. Conclusion: These results demonstrate that elevated LOXL2 levels are positively associated with poor prognosis in NSCLC patients. LOXL2 might therefore serve as a novel prognostic biomarker and potential therapeutic target in NSCLC patients. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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