Physicochemical characteristics and in vitro permeation of loratadine solid lipid nanoparticles for transdermal delivery
| Autor: | Omar Sarheed, Markus Drechsler, Joshua S. Boateng, Muhammad Amin, K. V. R. N. S. Ramesh, Douha Shouqair |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Chromatography
Chemistry Synthetic membrane Pharmaceutical Science 02 engineering and technology Permeation Loratadine 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Pig skin In vitro permeation Solid lipid nanoparticle medicine QD 0210 nano-technology Phase inversion QC Transdermal medicine.drug |
| ISSN: | 2041-5990 |
| Popis: | Aim:\ud To prepare loratadine-loaded solid lipid nanoparticles (SLNs) using a modified two-step ultrasound-assisted phase inversion temperature (PIT) process.\ud \ud Results/methodology:\ud Loratadine was dissolved in beeswax and Tween 80 was dissolved in water. The two phases were mixed together to prepare a water-in-oil emulsion preconcentrate (w/o) at a PIT of 85°C, followed by gradual water addition at 25°C to trigger nanoparticles formation (o/w). Kinetic stability was investigated. No change in the size was observed within 6 months. Fourier-transform infrared spectroscopy demonstrated stability of the emulsions via molecular structure of water at the interface of the o/w nanoemulsions. SLNs enhanced the in vitro skin permeation of loratadine.\ud \ud Conclusion:\ud Stable SLNs were successfully prepared by ultrasound-assisted PIT. |
| Databáze: | OpenAIRE |
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