BMI variation increases recurrence risk in women with early-stage breast cancer
| Autor: | Paola Schiavone, E. Mazzoni, Palma Fedele, Antonino Ardizzone, Chiara Caliolo, Saverio Cinieri, Isabella Sperduti, A. Marino, Emilio Bria, Assunta Maria Lapolla, Nicola Calvani, Annamaria Quaranta, Laura Orlando, Maria De Pasquale |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty Multivariate analysis recurrence Antineoplastic Agents Hormonal Breast Neoplasms Kaplan-Meier Estimate Disease Disease-Free Survival Body Mass Index Recurrence risk BMI Breast cancer Risk Factors Weight loss Internal medicine medicine Humans Stage (cooking) skin and connective tissue diseases Aged Proportional Hazards Models Retrospective Studies Aged 80 and over business.industry weight gain weight loss General Medicine Middle Aged Prognosis medicine.disease Tamoxifen Treatment Outcome Increased risk Multivariate Analysis Female Neoplasm Recurrence Local medicine.symptom business Weight gain |
| Popis: | ABSTRACT Aims: The prognostic role of BMI variation during and/or after treatments for early-stage breast cancer is still unknown. Patients & methods: The χ2 test was conducted to explore the correlation between breast cancer recurrence and BMI changes in 520 early-stage breast cancer patients. Cox proportional hazard models were used to analyze the association of BMI changes, baseline BMI, known prognostic factors and recurrences. Results: BMI gain was significant determinant of recurrences (p = 0.0008). In multivariate analyses, BMI variation more than 5.71% was associated with higher rates of recurrences, as well as age less than 55 years, stage disease and molecular subtype. Conclusion: Women who experience BMI gain after breast cancer may be at increased risk of poor outcomes. |
| Databáze: | OpenAIRE |
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