Skeletal Muscle Attenuation (Sarcopenia) Predicts Reduced Overall Survival in Patients with Advanced Epithelial Ovarian Cancer Undergoing Primary Debulking Surgery
| Autor: | Martin K. Walz, Pier Francesco Alesina, Florian Heitz, Stephanie Schneider, Teresa González Luengo, Kai-Uwe Waltering, Sebastian Heikaus, Beyhan Ataseven, Sonia Prader, Philipp Harter, Violeta Brunkhorst, Beate Meier, Andreas du Bois, Jens-Albrecht Koch, Pauly Nina, Alexander Traut, Harald-Thomas Groeben |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Sarcopenia medicine.medical_specialty Population Carcinoma Ovarian Epithelial Body Mass Index Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans 030212 general & internal medicine Muscle Skeletal education Survival rate Aged Retrospective Studies Aged 80 and over education.field_of_study Proportional hazards model business.industry Hazard ratio Cytoreduction Surgical Procedures Middle Aged Prognosis medicine.disease Debulking Surgery Survival Rate Oncology 030220 oncology & carcinogenesis Female Median body business Body mass index Follow-Up Studies |
| Zdroj: | Annals of Surgical Oncology. 25:3372-3379 |
| ISSN: | 1534-4681 1068-9265 |
| DOI: | 10.1245/s10434-018-6683-3 |
| Popis: | Sarcopenia was reported as a prognostic factor in cancer patients. Using computed tomography (CT), we analyzed the impact of sarcopenia on overall survival (OS) in patients with advanced epithelial ovarian cancer (EOC) after primary debulking surgery (PDS). Preoperative CT scans of consecutive EOC patients (n = 323) were retrospectively assessed for skeletal muscle index (SMI) and muscle attenuation (MA; Hounsfield units [HU]). The optimal cut-off point for MA (32 HU) was calculated using the Martingale residuals method, and previously reported cut-offs for SMI were used. Logistic regression was used to determine univariate and multivariate factors associated with OS. Sarcopenia defined as SMI 0 (13.2 vs. 3.1%), comorbidity (age-adjusted Charlson Comorbidity Index [ACCI] ≥ 4; 36.8 vs. 13.3%), median body mass index (BMI; 27 vs. 24 kg/m2), International Federation of Gynecology and Obstetrics (FIGO) stage, histology (high-grade serous 95.6 vs. 84.7%), and complete resection (38.2 vs. 68.2%). MA |
| Databáze: | OpenAIRE |
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