Pharmacokinetics of metoprolol during pregnancy and lactation
| Autor: | Sara Eyal, Danny D. Shen, Mary F. Hebert, Brian Phillips, Kenneth E. Thummel, Gary D.V. Hankins, Matthew T. Honaker, Linda J. Risler, Erik Rytting, Edward J. Kelly, Raman Venkataraman, Rachel J. Ryu, Thomas R. Easterling, Steve N. Caritis |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
medicine.medical_specialty Genotype Adrenergic beta-Antagonists Urine 030204 cardiovascular system & hematology Breast milk 030226 pharmacology & pharmacy Gastroenterology Article Young Adult 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Pregnancy Internal medicine Lactation Humans Medicine Pharmacology (medical) Metoprolol Pharmacology Milk Human business.industry Postpartum Period Infant exposure medicine.disease medicine.anatomical_structure Endocrinology Cytochrome P-450 CYP2D6 Delayed-Action Preparations Female business Postpartum period medicine.drug |
| Zdroj: | The Journal of Clinical Pharmacology. 56:581-589 |
| ISSN: | 0091-2700 |
| DOI: | 10.1002/jcph.631 |
| Popis: | The objective of this study was to evaluate the steady-state pharmacokinetics of metoprolol during pregnancy and lactation. Serial plasma, urine, and breast milk concentrations of metoprolol and its metabolite, α-hydroxymetoprolol, were measured over 1 dosing interval in women treated with metoprolol (25–750 mg/day) during early pregnancy (n = 4), mid-pregnancy (n = 14), and late pregnancy (n = 15), as well as postpartum (n = 9) with (n = 4) and without (n = 5) lactation. Subjects were genotyped for CYP2D6 loss-of-function allelic variants. Using paired analysis, mean metoprolol apparent oral clearance was significantly higher in mid-pregnancy (361 ± 223 L/h, n = 5, P < .05) and late pregnancy (568 ± 273 L/h, n = 8, P < .05) compared with ≥3 months postpartum (200 ± 131 and 192 ± 98 L/h, respectively). When the comparison was limited to extensive metabolizers (EMs), metoprolol apparent oral clearance was significantly higher during both mid- and late pregnancy (P < .05). Relative infant exposure to metoprolol through breast milk was |
| Databáze: | OpenAIRE |
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