Interleukin-6 and JAK2/STAT3 signaling mediate the reversion of dexamethasone resistance after dexamethasone withdrawal in 7TD1 multiple myeloma cells
| Autor: | Tuoen Liu, Christopher K. Daniels, Alok Bhushan, James C. K. Lai, Kalyan J. Gangavarapu, Shousong Cao, Senyo Agbenowu, Zhiqiang Fei |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
STAT3 Transcription Factor
Cancer Research Antineoplastic Agents Apoptosis Dexamethasone Article chemistry.chemical_compound Mice Cell Line Tumor medicine Animals Interleukin 6 STAT3 B cell Cell Proliferation biology Cell growth Interleukin-6 Hematology Janus Kinase 2 Tyrphostins medicine.anatomical_structure Oncology chemistry Cell culture Drug Resistance Neoplasm biology.protein Cancer research Growth inhibition Multiple Myeloma medicine.drug Signal Transduction |
| Zdroj: | Leukemia research. 37(10) |
| ISSN: | 1873-5835 |
| Popis: | We previously reported the establishment and characteristics of a DXM-resistant cell line (7TD1-DXM) generated from the IL6-dependent mouse B cell hybridoma, 7TD1 cell line. After withdrawing DXM from 7TD1-DXM cells over 90 days, DXM significantly inhibited the cell growth and induced apoptosis in the cells (7TD1-WD) compared with 7TD1-DXM cells. Additionally, IL-6 reversed while IL-6 antibody and AG490 enhanced the effects of growth inhibition and apoptosis induced by DXM in 7TD1-WD cells. Our study demonstrates that 7TD1-DXM cells become resensitized to DXM after DXM withdrawal, and IL-6 and JAK2/STAT3 pathways may regulate the phenomenon. |
| Databáze: | OpenAIRE |
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