SPARC and Vav3 Expression in Meningioma: Factors Related to Prognosis
| Autor: | Jiping Qi, Xiang Fang, Yuejia Song, Yu Sun, Shiguang Zhao, Jie Jiang, Zhen Zhang, Nan Liu, Chengjun Lin |
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| Rok vydání: | 2013 |
| Předmět: |
Oncology
VAV3 medicine.medical_specialty Resection Meningioma Cyclin D1 Internal medicine otorhinolaryngologic diseases Meningeal Neoplasms Medicine Humans Meningeal Neoplasm neoplasms Histopathologic Grade business.industry General Medicine Who grade medicine.disease Prognosis Immunohistochemistry nervous system diseases Neurology Neurology (clinical) Neoplasm Recurrence Local business |
| Zdroj: | The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. 40(6) |
| ISSN: | 0317-1671 |
| Popis: | Background:Meningiomas account for approximately 24-30% of primary intracranial neoplasms. Histopathologic grade and degree of resection are two major prognostic factors. The aim of this study was to determine the factors associated with the prognosis of meningioma.Methods:We used immunohistochemistry to analyze the expression levels of Vav3, SPARC, p-Akt, cyclin D1, and Ki-67 in 287 meningiomas of all grades.Results:The expression of Vav3, SPARC, p-Akt, cyclin D1, and Ki- 67 significantly increased with meningioma grade (pConclusion:The expression of Vav3, SPARC, p-Akt, cyclin D1, and Ki-67 in meningiomas appears to correlate with meningioma invasiveness, aggressiveness, and recurrence. |
| Databáze: | OpenAIRE |
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