Contrast Agent-Free Assessment of Blood Flow and Wall Shear Stress in the Rabbit Aorta using Ultrasound Image Velocimetry
| Autor: | Kai Riemer, Ethan M. Rowland, Jacob Broughton-Venner, Chee Hau Leow, Mengxing Tang, P.D. Weinberg |
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| Rok vydání: | 2021 |
| Předmět: |
Acoustics and Ultrasonics
Radiological and Ultrasound Technology Ultrasound image velocimetry Biophysics Echo-particle image velocimetry Hemodynamics 1103 Clinical Sciences Blood flow Acoustics Atherosclerosis Native blood speckle Wall shear stress Vector flow imaging Animals Radiology Nuclear Medicine and imaging Rabbits Stress Mechanical Rheology Shear Strength Blood speckle velocimetry Aorta Blood Flow Velocity Ultrasonography |
| Zdroj: | Ultrasound in medicinebiology. 48(3) |
| ISSN: | 1879-291X |
| Popis: | Blood flow velocity and wall shear stress (WSS) influence and are influenced by vascular disease. Their measurement is consequently useful in the laboratory and clinic. Contrast-enhanced ultrasound image velocimetry (UIV) can estimate them accurately but the need to inject contrast agents limits utility. Singular value decomposition and high-frame-rate imaging may render contrast agents dispensable. Here we determined whether contrast agent-free UIV can measure flow and WSS. In simulation, accurate measurements were achieved with a signal-to-noise ratio of 13.5 dB or higher. Signal intensity in the rabbit aorta increased monotonically with mechanical index; it was lowest during stagnant flow and uneven across the vessel. In vivo measurements with contrast-free and contrast-enhanced UIV differed by 4.4% and 1.9% for velocity magnitude and angle and by 9.47% for WSS. Bland-Altman analysis of waveforms revealed good agreement between contrast-free and contrast-enhanced UIV. In five rabbits, the root-mean-square errors were as low as 0.022 m/s (0.81%) and 0.11 Pa (1.7%). This study indicates that with an optimised protocol, UIV can assess flow and WSS without contrast agents. Unlike contrast-enhanced UIV, contrast-free UIV could be routinely employed. |
| Databáze: | OpenAIRE |
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