Prognostic Significance of bcr-1 and bcr-3 Isoforms of PML-RARA and FLT3-ITD in Patients With Acute Promyelocytic Leukemia
| Autor: | Ghada M. Elsayed, Mosaad M. El Gammal, Youssef Madney, Eman O Rasekh |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male FLT3 Internal Tandem Duplication Acute promyelocytic leukemia Oncology Cancer Research medicine.medical_specialty Adolescent Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Leukemia Promyelocytic Acute immune system diseases hemic and lymphatic diseases Internal medicine medicine Humans Protein Isoforms Child neoplasms Aged Disseminated intravascular coagulation business.industry breakpoint cluster region Infant Cancer Hematology Middle Aged Prognosis medicine.disease Survival Analysis Leukemia Retinoic acid receptor alpha Child Preschool 030220 oncology & carcinogenesis Proto-Oncogene Proteins c-bcr Female business 030215 immunology Cohort study |
| Zdroj: | Clinical Lymphoma Myeloma and Leukemia. 20:156-167 |
| ISSN: | 2152-2650 |
| DOI: | 10.1016/j.clml.2019.08.006 |
| Popis: | Background Acute promyelocytic leukemia (APL) has a characteristic peculiar morphologic and genetic features as well as a more favorable outcome. We studied the differential effect of bcr-1 and bcr-3 isoforms of the promyelocytic leukemia/retinoic acid receptor alpha (PML-RARA) transcript together with FLT3 internal tandem duplication (FLT3-ITD) mutation status on the outcome of newly diagnosed de novo APL patients. Patients and Methods This cohort study included all patients diagnosed with APL at outpatient medical and pediatric oncology clinics of the National Cancer Institute, Cairo University, Cairo, Egypt, from May 2012 to January 2018. Results The study included 118 patients with APL, 71 adults (60.2%) and 47 children (39.8%). Median (range) age was 25 (1.5-70) years. Children had significantly higher total leukocyte count (≥10 × 109/L), disseminated intravascular coagulation (DIC), and thrombocytopenia ( Conclusion Age is an independent prognostic factor for APL. bcr-3 is significantly associated with FLT3-ITD in adults with APL. DIC and FLT3-ITD are adverse prognostic factors in children with APL. Despite children being at higher risk, outcome is better than in adults. |
| Databáze: | OpenAIRE |
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