5-Formylcytosine can be a stable DNA modification in mammals
| Autor: | Santiago Uribe-Lewis, Adele Murrell, Martin Bachman, Heather E. Burgess, Mario Iurlaro, Wolf Reik, Shankar Balasubramanian, Xiaoping Yang |
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| Přispěvatelé: | Reik, Wolf [0000-0003-0216-9881], Balasubramanian, Shankar [0000-0002-0281-5815], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Aging
Biology Article Cytosine Mice chemistry.chemical_compound In vivo Animals DNA (Cytosine-5-)-Methyltransferases Molecular Biology Demethylation Myocardium Brain Gene Expression Regulation Developmental DNA Cell Biology DNA Methylation Mice Inbred C57BL 5-Methylcytosine DNA demethylation Animals Newborn Liver chemistry Biochemistry DNA methylation Nucleic acid Half-Life |
| Zdroj: | Bachman, M, Uribe-Lewis, S, Yang, X, Burgess, H E, Iurlaro, M, Reik, W, Murrell, A & Balasubramanian, S 2015, ' 5-Formylcytosine can be a stable DNA modification in mammals ', Nature Chemical Biology, vol. 11, no. 8, pp. 555-557 . https://doi.org/10.1038/nchembio.1848 |
| DOI: | 10.1038/nchembio.1848 |
| Popis: | 5-Formylcytosine (5fC) is a rare base found in mammalian DNA and thought to be involved in active DNA demethylation. Here, we show that developmental dynamics of 5fC levels in mouse DNA differ from those of 5-hydroxymethylcytosine (5hmC), and using stable isotope labeling in vivo, we show that 5fC can be a stable DNA modification. These results suggest that 5fC has functional roles in DNA that go beyond being a demethylation intermediate. |
| Databáze: | OpenAIRE |
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